| Title: |
The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density |
| Authors: |
Slater, Hannah, C; Ross, Amanda; Felger, Ingrid; Hofmann, Natalie, E; Robinson, Leanne; Cook, Jackie; Gonçalves, Bronner, P; Björkman, Anders; Ouedraogo, Andre, Lin; Morris, Ulrika; Msellem, Mwinyi; Koepfli, Cristian; Mueller, Ivo; Tadesse, Fitsum; Gadisa, Endalamaw; Das, Smita; Domingo, Gonzalo; Kapulu, Melissa; Midega, Janet; Owusu-Agyei, Seth; Nabet, Cécile; Piarroux, Renaud; Doumbo, Ogobara; Doumbo, Safiatou, Niare; Koram, Kwadwo; Lucchi, Naomi; Udhayakumar, Venkatachalam; Mosha, Jacklin; Tiono, Alfred; Chandramohan, Daniel; Gosling, Roly; Mwingira, Felista; Sauerwein, Robert; Paul, Richard, E.; Riley, Eleanor, M; White, Nicholas, J; Nosten, Francois; Imwong, Mallika; Bousema, Teun; Drakeley, Chris; Okell, Lucy, C |
| Contributors: |
Imperial College London; Swiss Tropical and Public Health Institute Basel; Université de Bâle = University of Basel = Basel Universität (Unibas); Papua New Guinea Institute for Medical Research (PNGIMR); The Walter and Eliza Hall Institute of Medical Research (WEHI); University of Melbourne; Burnet Institute Melbourne, Victoria; London School of Hygiene and Tropical Medicine (LSHTM); Karolinska Institutet = Karolinska Institute Stockholm; Centre National de Recherche et de Formation sur le Paludisme Ouagadougou, Burkina Faso (CNRFP); Institute for Disease Modeling (IDM); Mnazi Mmoja Hospital, Zanzibar; University of Notre Dame Indiana (UND); Département Parasites et Insectes vecteurs - Department of Parasites and Insect Vectors; Institut Pasteur Paris (IP); Radboud University Medical Center Nijmegen (RadboudUMC); Armauer Hansen Research Institute (AHRI); Addis Ababa University (AAU); Diagnostics Program Seattle, WA, USA (PATH); University of Oxford; University of Health and Allied Sciences Ho (UHAS); Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); CHU Pitié-Salpêtrière AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Université des Sciences, des Techniques et des Technologies de Bamako (USTTB); Université du Ghana = University of Ghana; Centers for Disease Control and Prevention Atlanta (CDC); Centers for Disease Control and Prevention; Mwanza Medical Research Centre Mwanza, Tanzania; University of California San Francisco (UC San Francisco); University of California (UC); Dares Salaam University College of Education; Institut Pasteur de Dakar; Pasteur Network (Réseau International des Instituts Pasteur); The University of Edinburgh; Mahidol University Bangkok; H.C.S. would like to acknowledge funding support from an Imperial College JuniorResearch Fellowship. L.C.O. acknowledges funding from a UK Royal Society DorothyHodgkin fellowship, the Bill & Melinda Gates Foundation and Medicines for MalariaVenture. R.Pa. would like to acknowledge funding from the Strategic Anopheles Hor-izontal Research Programme, Institut Pasteur. H.C.S. and L.C.O. acknowledge jointCentre funding from the UK Medical Research Council and Department for Interna-tional Development. |
| Source: |
ISSN: 2041-1723. |
| Publisher Information: |
CCSD; Nature Publishing Group |
| Publication Year: |
2019 |
| Subject Terms: |
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases; [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology |
| Description: |
International audience ; Malaria infections occurring below the limit of detection of standard diagnostics are common in all endemic settings. However, key questions remain surrounding their contribution to sustaining transmission and whether they need to be detected and targeted to achieve malaria elimination. In this study we analyse a range of malaria datasets to quantify the density, detectability, course of infection and infectiousness of subpatent infections. Asymptomatically infected individuals have lower parasite densities on average in low transmission settings compared to individuals in higher transmission settings. In cohort studies, subpatent infections are found to be predictive of future periods of patent infection and in membrane feeding studies, individuals infected with subpatent asexual parasite densities are found to be approximately a third as infectious to mosquitoes as individuals with patent (asexual parasite) infection. These results indicate that subpatent infections contribute to the infectious reservoir, may be long lasting, and require more sensitive diagnostics to detect them in lower transmission settings. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30926893; PUBMED: 30926893; PUBMEDCENTRAL: PMC6440965 |
| DOI: |
10.1038/s41467-019-09441-1 |
| Availability: |
https://hal.science/hal-03533031; https://hal.science/hal-03533031v1/document; https://hal.science/hal-03533031v1/file/Slater%20et%20al.%202019.pdf; https://doi.org/10.1038/s41467-019-09441-1 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.66F5C9E4 |
| Database: |
BASE |