Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study
| Title: | Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study |
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| Authors: | Giacomo Montagna; Alison Laws; Massimo Ferrucci; Mary M. Mrdutt; Susie X. Sun; Suleyman Bademler; Hakan Balbaloglu; Nora Balint-Lahat; Maggie Banys-Paluchowski; Andrea V. Barrio; John Benson; Nuran Bese; Judy C. Boughey; Marissa K. Boyle; Emilia J. Diego; Claire Eden; Ruth Eller; Maite Goldschmidt; Callie Hlavin; Martin Heidinger; Justyna Jelinska; Güldeniz Karadeniz Cakmak; Susan B. Kesmodel; Tari A. King; Henry M. Kuerer; Julie Loesch; Francesco Milardi; Dawid Murawa; Tracy-Ann Moo; Tehillah S. Menes; Daniele Passeri; Jessica M. Pastoriza; Andraz Perhavec; Nina Pislar; Natália Polidorio; Avina Rami; Jai Min Ryu; Alexandra Schulz; Varadan Sevilimedu; M. Umit Ugurlu; Cihan Uras; Annemiek van Hemert; Stephanie M. Wong; Tae-Kyung Robyn Yoo; Jennifer Q. Zhang; Hasan Karanlik; Neslihan Cabioğlu; Marie-Jeanne Vrancken Peeters; Monica Morrow; Walter P. Weber; Sung Gwe Ahn; Mariacarla Andreozzi; Daniel Meirelles Barbalho; Jean François Boileau; Edi Brogi; Flavia Vidal Cabero; Daniela Cocco; Fabio Corsi; Angelena Crown; Eelco de Bree; Maria del Mar Vernet-Tomas; Christine Deutschmann; Nina Ditsch; Emanuela Esposito; Oluwadamilola M. Fayanju; Franziska Fick; Florian Fitzal; Meghan R. Flanagan; Damiano Gentile; Oreste D. Gentilini; Anne Grabenstetter; Mehmet Ali Gulcelik; Jörg Heil; Johannes Holtschmidt; Natalia Krawczyk; Thorsten Kühn; Sherko Kümmel; Cornelia Leo; Mahmut Muslumanoglu; Valentina Nekljudova; Lisa A. Newman; Melissa L. Pilewskie; Fiorita Poulakaki; Fabian Riedel; Nicola Rocco; Freya R. Schnabel; Christopher Schwartz; Emily L. Siegel; Colin Simonson; Christian Singer; Leonardo Ribeiro Soares; Ekaterini Christina Tampaki; Athanasios Tampakis; Marios Konstantinos Tasoulis; Christoph Tausch; Cicero Urban; Astrid Botty Van den Bruele; Glenn Vergauwen; Denise Vorburger; Fredrik Wärnberg |
| Publisher Information: | American Society of Clinical Oncology (ASCO) |
| Publication Year: | 2025 |
| Subject Terms: | Adult; Neoplasm; Residual; Sentinel Lymph Node Biopsy; Breast Neoplasms; ORIGINAL REPORTS; Middle Aged; Neoadjuvant Therapy; 03 medical and health sciences; Treatment Outcome; 0302 clinical medicine; Chemotherapy; Adjuvant; Lymphatic Metastasis; Axilla; Humans; Lymph Node Excision; Female; Lymph Nodes; Sentinel Lymph Node; Neoplasm Recurrence; Local; Retrospective Studies; Aged; Neoplasm Staging |
| Description: | PURPOSE The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management is not standardized. We investigated rates of additional positive lymph nodes (LNs) at axillary lymph node dissection (ALND) and oncologic outcomes in patients with ypN0i+ treated with and without ALND. METHODS The Oncoplastic Breast Consortium-05/ICARO cohort study (ClinicalTrials.gov identifier: NCT06464341 ) retrospectively analyzed data from patients with stage I to III breast cancer with ITCs in SLNs after NAC from 62 centers in 18 countries. The primary end point was the 3-year rate of any axillary recurrence. The rate of any invasive recurrence was the secondary end point. RESULTS In total, 583 patients were included, of whom 182 (31%) had completion ALND and 401 (69%) did not. The median age was 48 years. Most patients (74%) were clinically node-positive at diagnosis and 41% had hormone receptor–positive/human epidermal growth factor receptor 2–negative tumors. The mean number of SLNs with ITCs was 1.2. Patients treated with ALND were more likely to present with cN2/3 disease (17% v 7%, P < .001), have ITCs detected on frozen section (62% v 8%, P < .001), have lymphovascular invasion (38% v 24%, P < .001), and receive adjuvant chest wall ... |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| ISSN: | 39509672 |
| Relation: | Journal of Clinical Oncology; https://hdl.handle.net/20.500.12628/29381; 001432096800009; 810; 820; 43 |
| DOI: | 10.1200/jco.24.01052 |
| Availability: | https://hdl.handle.net/20.500.12628/29381; https://doi.org/10.1200/jco.24.01052 |
| Rights: | OPEN |
| Accession Number: | edsbas.6723FCC2 |
| Database: | BASE |