| Title: |
Spatiotemporal dynamics and regulation of suture morphology and collagen remodeling during trans-sutural distraction osteogenesis |
| Authors: |
Zhiyu Lin; Yujie Chen; Peiyang Zhang; Mengying Jin; Yan Zha; Zhenmin Zhao |
| Source: |
npj Regenerative Medicine, Vol 11, Iss 1, Pp 1-16 (2026) |
| Publisher Information: |
Nature Portfolio |
| Publication Year: |
2026 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Medicine |
| Description: |
Trans-sutural distraction osteogenesis (TSDO) is an effective treatment of midfacial hypoplasia, a craniofacial deformity frequently associated with cleft lip and palate. Though extracellular matrix (ECM) remodeling plays a pivotal role in craniofacial correction, the characteristics and mechanisms underlying collagen reorganization and cellular morphological adaptations during TSDO remain poorly understood. This study quantitatively delineates the spatiotemporal changes of sutural cells and ECM morphology, revealing a polarized alignment parallel to the direction of mechanical force. Multi-omics analysis demonstrates that macrophages regulate collagen remodeling in suture mesenchymal stem cells (SuSCs) via the PDGF signaling pathway. Subsequent in vitro stretch loading models confirmed PDGF pathway activation enhances SuSCs migration, collagen synthesis, and cellular morphological reorganization. Validation in macrophage-elimination murine models further corroborated this regulatory axis. Collectively, our work maps the dynamic microenvironmental changes during TSDO and elucidates cell-cell interaction-driven ECM collagen remodeling. These insights advance the understanding of TSDO-mediated osteogenesis and provide a foundation for developing optimized therapeutic strategies. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1038/s41536-025-00448-5; https://doaj.org/toc/2057-3995; https://doaj.org/article/259ebdc075e54293b862ac1842b45b52 |
| DOI: |
10.1038/s41536-025-00448-5 |
| Availability: |
https://doi.org/10.1038/s41536-025-00448-5; https://doaj.org/article/259ebdc075e54293b862ac1842b45b52 |
| Accession Number: |
edsbas.67962839 |
| Database: |
BASE |