Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease:the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study
| Title: | Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease:the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study |
|---|---|
| Authors: | Constantine-Cooke, Nathan; Gros, Beatriz; Plevris, Nikolas; Williams, Linda J.; Jones, Gareth Rhys; Kyle, Janet; Kennedy, Nicholas A.; Velasco-Pardo, Victor; Rudge, Alexander; Alexander, Debbie; Anderson, Carl A.; de Freitas, Maiara Brusco; Derr, Lisa M.; Derikx, Lauranne A.A.P.; Gilchrist, Sian; Henderson, Paul; Horgan, Graham W.; Irving, Peter; Lamb, Christopher A.; Jostins-Dean, Luke; Lindsay, James O.; MacDonald, Jonathan; Mowat, Craig; Murray, Charles; Parkes, Miles; Siakavellas, Spyros I.; Vallejos, Catalina A.; Gaya, Daniel R.; Rhodes, Jonathan M.; Johnstone, Alexandra M.; Weir, Christopher J.; Lees, Charlie W. |
| Source: | Constantine-Cooke, N, Gros, B, Plevris, N, on behalf of the PREdiCCt study group, Williams, L J, Jones, G R, Kyle, J, Kennedy, N A, Velasco-Pardo, V, Rudge, A, Alexander, D, Anderson, C A, de Freitas, M B, Derr, L M, Derikx, L A A P, Gilchrist, S, Henderson, P, Horgan, G W, Irving, P, Lamb, C A, Jostins-Dean, L, Lindsay, J O, MacDonald, J, Mowat, C, Murray, C, Parkes, M, Siakavellas, S I, Vallejos, C A, Gaya, D R, Rhodes, J M, Johnstone, A M, Weir, C J & Lees, C W 2026, 'Associations between demographic, clinical and dietary .... |
| Publication Year: | 2026 |
| Description: | Background IBD is characterised by recurrent flares, but evidence on whether modifiable dietary factors influence flare risk is limited. Objective The PREdiCCt study was designed to examine demographic, clinical and dietary factors associated with disease flare among patients with IBD in self-reported remission. Design Multicentre, prospective cohort study conducted across 47 UK centres. Patients with Crohn’s disease (CD), ulcerative colitis (UC) or IBD unclassified (IBDU) in self-reported remission were prospectively followed up. The baseline diet was assessed using a validated food frequency questionnaire. The primary outcome was time to patient-reported flare (captured by monthly IBD-Control) and objective flare (clinical flare plus C-reactive protein >5 mg/L and/or faecal calprotectin (FC) >250 µg/g with treatment escalation). Associations were evaluated using Cox frailty models adjusted for demographic, clinical and biochemical variables, including baseline FC. Results Between November 2016 and March 2020, 2629 participants (1370CD; 1259 UC/IBDU) were enrolled and followed up for a median of 4.1 years (IQR 3.0–5.0). Baseline FC was strongly associated with patient-reported flares (FC ≥250µg/g: adjusted HR (aHR) 2.22; FC 50–250µg/g: aHR 1.52 (reference |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0017-5749; 1468-3288 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/41554630; info:eu-repo/semantics/altIdentifier/pissn/0017-5749; info:eu-repo/semantics/altIdentifier/eissn/1468-3288 |
| DOI: | 10.1136/gutjnl-2025-337846 |
| Availability: | https://pure.eur.nl/en/publications/995d73a1-bc22-430b-939c-748361f43eba; https://doi.org/10.1136/gutjnl-2025-337846; https://pure.eur.nl/ws/files/229127602/gutjnl-2025-337846.full.pdf; https://www.scopus.com/pages/publications/105028010963 |
| Rights: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.679D8F34 |
| Database: | BASE |