| Title: |
Fight INflammation to Improve outcome after aneurysmal Subarachnoid HEmorRhage (FINISHER) trial: Study protocol for a randomized controlled trial |
| Authors: |
Güresir, Erdem; Lampmann, Tim; Bele, Sylvia; Czabanka, Marcus; Czorlich, Patrick; Gempt, Jens; Goldbrunner, Roland; Hurth, Helene; Hermann, Elvis; Jabbarli, Ramazan; Krauthausen, Marius; König, Ralph; Lindner, Dirk; Malinova, Vesna; Meixensberger, Jürgen; Mielke, Dorothee; Németh, Robert; Darkwah Oppong, Marvin; Pala, Andrej; Prinz, Vincent; Rashidi, Ali; Roder, Constantin; Sandalcioglu, Ibrahim Erol; Sauvigny, Thomas; Schebesch, Karl-Michael; Timmer, Marco; Vajkoczy, Peter; Wessels, Lars; Wild, Florian; Wilhelm, Christoph; Wostrack, Maria; Vatter, Hartmut; Coch, Christoph |
| Publisher Information: |
SAGE |
| Publication Year: |
2023 |
| Collection: |
Universität Leipzig: Qucosa |
| Subject Terms: |
Dexamethasone; glucocorticoid; aneurysm; subarachnoid hemorrhage; inflammation; clinical trail; info:eu-repo/classification/ddc/610; ddc:610 |
| Description: |
Aneurysmal subarachnoid hemorrhage (SAH) has high morbidity and mortality. While the primary injury results from the initial bleeding cannot currently be influenced, secondary injury through vasospasm and delayed cerebral ischemia worsens outcome and might be a target for interventions to improve outcome. To date, beside the aneurysm treatment to prevent re-bleeding and the administration of oral nimodipine, there is no therapy available, so novel treatment concepts are needed. Evidence suggests that inflammation contributes to delayed cerebral ischemia and poor outcome in SAH. Some studies suggest a beneficial effect of anti-inflammatory glucocorticoids, but there are no data from randomized controlled trials examining the efficacy of glucocorticoids. Therefore, current guidelines do not recommend the use of glucocorticoids in SAH. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://ul.qucosa.de/id/qucosa%3A97553 |
| Availability: |
https://nbn-resolving.org/urn:nbn:de:bsz:15-qucosa2-975532; https://ul.qucosa.de/id/qucosa%3A97553; https://ul.qucosa.de/api/qucosa%3A97553/attachment/ATT-0/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.67B305F9 |
| Database: |
BASE |