| Title: |
Living-Donor Uterus Transplantation: A Clinical Review |
| Authors: |
Massimiliano Veroux; Paolo Scollo; Martina Maria Giambra; Giuseppe Roscitano; Alessia Giaquinta; Francesco Setacci; Pierfrancesco Veroux |
| Source: |
Journal of Clinical Medicine, Vol 13, Iss 3, p 775 (2024) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2024 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
Mayer–Rokitansky–Küster–Hauser syndrome; hysterectomy; robotic; laparoscopic; live births; deceased donor; Medicine |
| Description: |
Uterus transplantation (UTx) is currently the only available treatment for absolute uterine factor infertility. More than 90 uterus transplantations have been performed worldwide, mostly from living donors. Living-donor (LD) UTx is a challenging surgical procedure since it poses ethical issues, and it is a high-risk and invasive surgery with higher hysterectomy-related risks compared to conventional hysterectomy. A total of 59 living-donor hysterectomies have been reported in the literature, including 35 performed with a laparotomic approach, 20 with a robotic approach and 4 with a laparoscopic approach. The mean donor age was 45.6 ± 9.1 years, and 22 were unrelated with the recipients, 34 were emotionally related (27 mothers, 5 sisters, 2 mother’s sisters). The mean recipient age was 28.8 ± 4.5 years. Mayer–Rokitansky–Küster–Hauser syndrome was the most common indication for uterus transplant. Robotic living-donor hysterectomy had the longest operative time but resulted in a lower blood loss and postoperative stay compared to laparotomic and laparoscopic approaches. Twenty-nine births from LD-UTx have been reported, four after robotic living-donor hysterectomy and twenty-five after a laparotomic procedure. UTx is now an effective treatment for women with UFI. While living-donor UTx in some cases may be considered an experimental procedure, it offers the extraordinary possibility to give women the opportunity to have a pregnancy. Many efforts should be made to reduce the potential risks for donors, including the use of mini-invasive techniques, and the efficacy of UTx in the recipients, giving the potential harm of immunosuppression in a recipient of a non-life-saving organ. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISBN: |
978-7-272-88187-2; 7-272-88187-9 |
| Relation: |
https://www.mdpi.com/2077-0383/13/3/775; https://doaj.org/toc/2077-0383; https://doaj.org/article/7272881879504153aef419adeb698489 |
| DOI: |
10.3390/jcm13030775 |
| Availability: |
https://doi.org/10.3390/jcm13030775; https://doaj.org/article/7272881879504153aef419adeb698489 |
| Accession Number: |
edsbas.67EB0984 |
| Database: |
BASE |