| Title: |
Features of Invasive Aspergillosis Caused by Aspergillus flavus , France, 2012–2018 |
| Authors: |
Bertin-Biasutto, Lise; Paccoud, Olivier; Garcia-Hermoso, Dea; Denis, Blandine; Boukris-Sitbon, Karine; Lortholary, Olivier; Bretagne, Stéphane; Gits-Muselli, Maud; Herbrecht, Raoul; Letscher-Bru, Valérie; Danion, François; Cassaing, Sophie; Morio, Florent; Nourrisson, Céline; Pihet, Marc; Sasso, Milène; Desoubeaux, Guillaume; Durieux, Marie-Fleur; Bonhomme, Julie; Chachaty, Elisabeth; Chouaki, Taieb; Desbois-Nogard, Nicole; Alanio, Alexandre; Gangneux, Jean-Pierre; Lanternier, Fanny |
| Contributors: |
Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Université Paris Cité (UPCité); Institut Pasteur Paris (IP); Hopital Saint-Louis AP-HP (AP-HP); Institut de Cancérologie de Strasbourg Europe (ICANS); Hôpitaux Universitaires de Strasbourg (HUS); Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes); CHU Clermont-Ferrand; Centre Hospitalier Universitaire d'Angers (CHU Angers); Centre Hospitalier Universitaire de Nîmes (CHU Nîmes); Université de Montpellier (UM); Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Université de Limoges (UNILIM); Université de Caen Normandie (UNICAEN); Normandie Université (NU); Institut Gustave Roussy (IGR); CHU Amiens-Picardie; Glycobiologie de pathogenèse fongique et applications cliniques; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille; Centre Hospitalier Universitaire de Martinique Fort-de-France, Martinique (CHU de Martinique); Université de Rennes (UR); Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou; This work was supported by recurrent financial support from Santé Publique France and Institut Pasteur. |
| Source: |
ISSN: 1080-6040. |
| Publisher Information: |
CCSD; Centers for Disease Control and Prevention |
| Publication Year: |
2025 |
| Subject Terms: |
[SDV]Life Sciences [q-bio]; [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology |
| Description: |
International audience ; Invasive aspergillosis (IA) caused by Aspergillus flavus remains poorly described. We retrospectively analyzed 54 cases of IA caused by A. flavus reported in France during 2012–2018. Among cases, underlying IA risk factors were malignancy, solid organ transplantation, and diabetes. Most (87%, 47/54) infections were localized, of which 33 were pleuropulmonary and 13 were ear-nose-throat (ENT) infection sites. Malignancy (70% [23/33]) and solid organ transplantation (21% [7/33]) were the main risk factors in localized pulmonary infections, and diabetes mellitus was associated with localized ENT involvement (61.5%, [8/13]). Fungal co-infections were frequent in pulmonary (36%, 12/33) but not ENT IA (0 cases). Antifungal monotherapy was prescribed in 45/50 (90%) cases, mainly voriconazole (67%, 30/45). All-cause 30-day case-fatality rates were 39.2% and 90-day rates were 47.1%, and rates varied according to risk factor, IA site, and fungal co-infections. Clinicians should remain vigilant for A. flavus and consider it in the differential diagnosis for IA. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40305205; PUBMED: 40305205; PUBMEDCENTRAL: PMC12044239 |
| DOI: |
10.3201/eid3105.241392 |
| Availability: |
https://univ-angers.hal.science/hal-05169425; https://univ-angers.hal.science/hal-05169425v1/document; https://univ-angers.hal.science/hal-05169425v1/file/24-1392.pdf; https://doi.org/10.3201/eid3105.241392 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.67FE2910 |
| Database: |
BASE |