| Title: |
Statin therapy and thromboxane generation in patients with coronary artery disease treated with high-dose aspirin |
| Authors: |
Bliden, Kevin P.; Singla, Anand; Gesheff, Martin G.; Toth, Peter P.; Tabrizchi, Ali; Ens, Gordon; Guyer, Kirk; Singh, Mandeep; Franzese, Christopher J.; Stapleton, Dwight D.; Tantry, Udaya S.; Gurbel, Paul A. |
| Source: |
Thrombosis and Haemostasis ; volume 112, issue 08, page 323-331 ; ISSN 0340-6245 2567-689X |
| Publisher Information: |
Georg Thieme Verlag KG |
| Publication Year: |
2014 |
| Description: |
Summary Aspirin and statin therapy are mainstay treatments in patients with coronary artery disease (CAD). The relation between statin therapy, in vivo thromboxane (Tx) generation; a marker of inflammation, and blood thrombogenicity has never been explored. Urinary 11-dehydro (dh) TxB2 was determined in patients with suspected CAD on 325 mg daily aspirin therapy prior to undergoing cardiac catheterisation (n=281). Thrombogenicity was estimated by thrombelastographic measurement of thrombin-induced platelet-fibrin clot strength (TIP-FCS) and lipids/lipoproteins were determined by vertical density gradient ultracentrifugation/ELISA. The influence of statin therapy and dose was analysed by the atorvastatin equivalent dose (5–10 mg, 20–40 mg, or 80 mg daily). Statin therapy (n=186) was associated with a dose-dependent reduction in urinary 11-dh TxB2 (p=0.046) that was independent of LDL and apo B100 levels but was strongly related to TIP-FCS (p=0.006). By multivariate analysis, no statin therapy (n=95) and female gender were independently associated with high urinary 11-dh TxB2 [OR=2.95 (0.1.57–5.50, p=0.0007); OR=2.25 (1.24–4.05, p=0.007)], respectively. In aspirin-treated patients, statin therapy was independently and inversely associated with inflammation in a dose-dependent manner. Elevated 11-dh TxB2 was associated with a prothrombotic state indicated by high TIP-FCS. Our data suggest that measurement of urinary 11-dTxB2 may be a useful method to optimise statin dosing in order to reduce thrombotic risk. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1160/th14-01-0094 |
| DOI: |
10.1160/TH14-01-0094.pdf |
| Availability: |
https://doi.org/10.1160/th14-01-0094; http://www.thieme-connect.de/products/ejournals/pdf/10.1160/TH14-01-0094.pdf |
| Accession Number: |
edsbas.6800C912 |
| Database: |
BASE |