| Title: |
Elimination of Middle-Sized Uremic Solutes with High-Flux and High-Cut-Off Membranes: A Randomized in vivo Study. |
| Authors: |
Kneis, C.; Beck, W.; Boenisch, O.; Klefisch, F.; Deppisch, R.; Zickler, D.; Schindler, R. |
| Contributors: |
Institut de génétique et microbiologie Orsay (IGM); Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS) |
| Source: |
ISSN: 0253-5068. |
| Publisher Information: |
CCSD; Karger |
| Publication Year: |
2013 |
| Subject Terms: |
[SDV.BBM]Life Sciences [q-bio]/Biochemistry; Molecular Biology; [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology |
| Description: |
International audience ; The elimination of substances between 10 and 50 kDa by conventional high-flux membranes is not satisfactory. We investigated in vivo the elimination of middle-sized uremic solutes by conventional polyflux (PF) and modified high-cut-off (HCO) membranes. All 12 patients underwent four treatments, two with the HCO dialyzer and two with the PF dialyzer, each in either a haemodialysis (HD) or haemodiafiltration (HDF) mode. The reduction ratio of urea, creatinine, β2-microglobulin (β2M), leptin, soluble TNF-RI, complement factor D, IL-6, sIL-6 receptor, advanced glycation end-products (AGEs) and albumin was determined. In addition, the amount removed was determined in the dialysate for β2M, complement factor D, AGEs and albumin. Treatment with HCO removed β2M, sTNF-RI, factor D, and high molecular AGE significantly better than conventional high-flux membranes. The albumin loss was higher when using HCO membranes. HCO membranes are a promising approach to improve removal of uremic toxins not affected by conventional high-flux membranes. © 2013 S. Karger AG, Basel. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/24496201; PUBMED: 24496201 |
| DOI: |
10.1159/000356224 |
| Availability: |
https://hal.science/hal-00942681; https://doi.org/10.1159/000356224 |
| Accession Number: |
edsbas.680B3304 |
| Database: |
BASE |