| Title: |
Prognostic implications of risk definitions from the monarchE and NATALEE trials |
| Authors: |
Arecco, Luca; Blondeaux, Eva; Bruzzone, Marco; Arpino, Grazia; De Angelis, Carmine; De Laurentiis, Michelino; Caputo, Roberta; Fabi, Alessandra; Sanna, Valeria; Gori, Stefania; Puglisi, Fabio; Boni, Luca; Nardin, Simone; Giannubilo, Irene; Perachino, Marta; Borea, Roberto; Agostinetto, Elisa; de Azambuja, Evandro; Lambertini, Matteo; Del Mastro, Lucia |
| Contributors: |
Arecco, Luca; Blondeaux, Eva; Bruzzone, Marco; Arpino, Grazia; De Angelis, Carmine; De Laurentiis, Michelino; Caputo, Roberta; Fabi, Alessandra; Sanna, Valeria; Gori, Stefania; Puglisi, Fabio; Boni, Luca; Nardin, Simone; Giannubilo, Irene; Perachino, Marta; Borea, Roberto; Agostinetto, Elisa; De Azambuja, Evandro; Lambertini, Matteo; Del Mastro, Lucia |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Genova: CINECA IRIS |
| Description: |
Background: The monarchE and NATALEE trials employed different high-risk inclusion criteria. Main objective is to assess prognostic differences based on their inclusion criteria. Methods: Patients with hormone receptor-positive/HER2-negative early breast cancer enrolled in the phase III MIG1, GIM2, and GIM3 trials were categorized as high-risk cohort (HRC) and low-risk cohort (LRC) according to the inclusion criteria of monarchE and NATALEE trials. Subsequently, they were further classified in three different cohortsconcordant LRC (low-risk for both trials), discordant risk cohort (high-risk for only one trial), and concordant HRC (high-risk for both trials). Main outcomes were disease-free survival (DFS) and overall survival (OS). Results: Among 4,795 patients included, 1,343 (28.0%) and 2,689 (56.1%) were classified as HRC according to the monarchE and NATALEE, respectively. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39908473; info:eu-repo/semantics/altIdentifier/wos/WOS:001456081100001; volume:117; issue:6; firstpage:1198; lastpage:1208; numberofpages:11; journal:JOURNAL OF THE NATIONAL CANCER INSTITUTE; https://hdl.handle.net/11567/1241836 |
| DOI: |
10.1093/jnci/djaf031 |
| Availability: |
https://hdl.handle.net/11567/1241836; https://doi.org/10.1093/jnci/djaf031 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.683B3897 |
| Database: |
BASE |