Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort
| Title: | Comparison of clinical rating scales in genetic frontotemporal dementia within the GENFI cohort |
|---|---|
| Authors: | Peakman G.; Russell L. L.; Convery R. S.; Nicholas J. M.; van Swieten J. C.; Jiskoot L. C.; Moreno F.; Sanchez-Valle R.; Laforce R.; Graff C.; Masellis M.; Tartaglia M. C.; Rowe J. B.; Borroni B.; Finger E.; Synofzik M.; Galimberti D.; Vandenberghe R.; de Mendonca A.; Butler C. R.; Gerhard A.; Ducharme S.; Le Ber I.; Tagliavini F.; Santana I.; Pasquier F.; Levin J.; Danek A.; Otto M.; Sorbi S.; Rohrer J. D.; Genetic FTD Initiative (GENFI); Afonso S.; Almeida M. R.; Anderl-Straub S.; Andersson C.; Antonell A.; Archetti S.; Arighi A.; Balasa M.; Barandiaran M.; Bargallo N.; Bartha R.; Bender B.; Benussi A.; Bertoux M.; Bertrand A.; Bessi V.; Black S.; Bocchetta M.; Borrego-Ecija S.; Bras J.; Brice A.; Bruffaerts R.; Camuzat A.; Canada M.; Cantoni V.; Caroppo P.; Cash D.; Castelo-Branco M.; Colliot O.; Cope T.; Deramecourt V.; de Arriba M.; Di Fede G.; Diez A.; Duro D.; Fenoglio C.; Ferrari C.; Ferreira C. B.; Fox N.; Freedman M.; Fumagalli G.; Funkiewiez A.; Gabilondo A.; Gasparotti R.; Gauthier S.; Gazzina S.; Giaccone G.; Gorostidi A.; Greaves C.; Guerreiro R.; Heller C.; Hoegen T.; Indakoetxea B.; Jelic V.; Karnath H. -O.; Keren R.; Kuchcinski G.; Langheinrich T.; Lebouvier T.; Leitao M. J.; Llado A.; Lombardi G.; Loosli S.; Maruta C.; Mead S.; Meeter L.; Miltenberger G.; van Minkelen R.; Mitchell S.; Moore K.; Nacmias B.; Nelson A.; Oijerstedt L.; Olives J.; Ourselin S.; Padovani A.; Panman J.; Papma J. M.; Pijnenburg Y.; Polito C.; Premi E.; Prioni S.; Prix C.; Rademakers R.; Redaelli V.; Rinaldi D.; Rittman T.; Rogaeva E.; Rollin A.; Rosa-Neto P.; Rossi G.; Rossor M.; Santiago B.; Saracino D.; Sayah S.; Scarpini E.; Schonecker S.; Seelaar H.; Semler E.; Shafei R.; Shoesmith C.; Swift I.; Tabuas-Pereira M.; Tainta M.; Taipa R.; Tang-Wai D.; Thomas D. L.; Thompson P.; Thonberg H.; Timberlake C.; Tiraboschi P.; Todd E.; van Damme P.; Vandenbulcke M.; Veldsman M.; Verdelho A.; Villanua J.; Warren J.; Wilke C.; Woollacott I.; Wlasich E.; Zetterberg H.; Zulaica M. |
| Contributors: | Peakman, G.; Russell, L. L.; Convery, R. S.; Nicholas, J. M.; van Swieten, J. C.; Jiskoot, L. C.; Moreno, F.; Sanchez-Valle, R.; Laforce, R.; Graff, C.; Masellis, M.; Tartaglia, M. C.; Rowe, J. B.; Borroni, B.; Finger, E.; Synofzik, M.; Galimberti, D.; Vandenberghe, R.; de Mendonca, A.; Butler, C. R.; Gerhard, A.; Ducharme, S.; Le Ber, I.; Tagliavini, F.; Santana, I.; Pasquier, F.; Levin, J.; Danek, A.; Otto, M.; Sorbi, S.; Rohrer, J. D.; Genetic FTD Initiative, (GENFI); Afonso, S.; Almeida, M. R.; Anderl-Straub, S.; Andersson, C.; Antonell, A.; Archetti, S.; Arighi, A.; Balasa, M.; Barandiaran, M.; Bargallo, N.; Bartha, R.; Bender, B.; Benussi, A.; Bertoux, M.; Bertrand, A.; Bessi, V.; Black, S.; Bocchetta, M.; Borrego-Ecija, S.; Bras, J.; Brice, A.; Bruffaerts, R.; Camuzat, A.; Canada, M.; Cantoni, V.; Caroppo, P.; Cash, D.; Castelo-Branco, M.; Colliot, O.; Cope, T.; Deramecourt, V.; de Arriba, M.; Di Fede, G.; Diez, A.; Duro, D.; Fenoglio, C.; Ferrari, C.; Ferreira, C. B.; Fox, N.; Freedman, M.; Fumagalli, G.; Funkiewiez, A.; Gabilondo, A.; Gasparotti, R.; Gauthier, S.; Gazzina, S.; Giaccone, G.; Gorostidi, A.; Greaves, C.; Guerreiro, R.; Heller, C.; Hoegen, T.; Indakoetxea, B.; Jelic, V.; Karnath, H. -O.; Keren, R.; Kuchcinski, G.; Langheinrich, T.; Lebouvier, T.; Leitao, M. J.; Llado, A.; Lombardi, G.; Loosli, S.; Maruta, C.; Mead, S.; Meeter, L.; Miltenberger, G.; van Minkelen, R. |
| Publication Year: | 2022 |
| Collection: | Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
| Subject Terms: | frontotemporal dementia |
| Description: | Background Therapeutic trials are now underway in genetic forms of frontotemporal dementia (FTD) but clinical outcome measures are limited. The two most commonly used measures, the Clinical Dementia Rating (CDR)+National Alzheimer's Disease Coordinating Center (NACC) Frontotemporal Lobar Degeneration (FTLD) and the FTD Rating Scale (FRS), have yet to be compared in detail in the genetic forms of FTD. Methods The CDR+NACC FTLD and FRS were assessed crosssectionally in 725 consecutively recruited participants from the Genetic FTD Initiative: 457 mutation carriers (77 microtubule-associated protein tau (MAPT), 187 GRN, 193 C9orf72) and 268 family members without mutations (non-carrier control group). 231 mutation carriers (51 MAPT, 92 GRN, 88 C9orf72) and 145 non-carriers had available longitudinal data at a follow-up time point. Results Cross-sectionally, the mean FRS score was lower in all genetic groups compared with controls: GRN mutation carriers mean 83.4 (SD 27.0), MAPT mutation carriers 78.2 (28.8), C9orf72 mutation carriers 71.0 (34.0), controls 96.2 (7.7), p |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34353857; info:eu-repo/semantics/altIdentifier/wos/WOS:000725021700001; volume:93; issue:2; firstpage:158; lastpage:168; numberofpages:11; journal:JOURNAL OF NEUROLOGY, NEUROSURGERY AND PSYCHIATRY; https://hdl.handle.net/11368/3097017; https://jnnp.bmj.com/content/93/2/158.long |
| DOI: | 10.1136/jnnp-2021-326868 |
| Availability: | https://hdl.handle.net/11368/3097017; https://doi.org/10.1136/jnnp-2021-326868; https://jnnp.bmj.com/content/93/2/158.long |
| Rights: | info:eu-repo/semantics/openAccess ; license:Creative commons ; license:Digital Rights Management non definito ; license uri:http://creativecommons.org/licenses/by/4.0/ ; license uri:iris.PRI00 |
| Accession Number: | edsbas.68E0AEA0 |
| Database: | BASE |