| Title: |
Synthesis and DNA cleavage studies of novel quinoline oxime esters |
| Authors: |
Bindu, PJ; Mahadevan, KM; Satyanarayan, ND; Naik, Ravikumar TR |
| Publisher Information: |
Elsevier Science |
| Publication Year: |
2012 |
| Collection: |
Indian Institute of Science, Bangalore: ePrints@IIsc |
| Subject Terms: |
Organic Chemistry |
| Description: |
New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0 degrees C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40 mu M and 80 mu M). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form. (C) 2011 Elsevier Ltd. All rights reserved. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
http://eprints.iisc.ernet.in/43674/1/Synthesis_and_DNA.pdf; Bindu, PJ and Mahadevan, KM and Satyanarayan, ND and Naik, Ravikumar TR (2012) Synthesis and DNA cleavage studies of novel quinoline oxime esters. In: Bioorganic & Medicinal Chemistry Letters, 22 (2). pp. 898-900. |
| Availability: |
http://eprints.iisc.ernet.in/43674/; http://eprints.iisc.ernet.in/43674/1/Synthesis_and_DNA.pdf |
| Accession Number: |
edsbas.68E1157A |
| Database: |
BASE |