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MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody–drug conjugates

Title: MMP-cleavable linker platform for tumour-responsive homo- and heterobivalent antibody–drug conjugates
Authors: Counsell, Andrew J.; Walsh, Stephen J.; Ashman, Nicola; Park, Mahri; Dannheim, Friederike M.; King, Thomas A.; Wharton, Thomas; Carroll, Jason S.; Spring, David R.
Contributors: Engineering and Physical Sciences Research Council; Biotechnology and Biological Sciences Research Council; UK Research and Innovation; Cystic Fibrosis Trust; Cancer Research UK
Source: Chemical Science ; volume 17, issue 5, page 2722-2731 ; ISSN 2041-6520 2041-6539
Publisher Information: Royal Society of Chemistry (RSC)
Publication Year: 2026
Description: Herein we report the development of a novel linker platform for tumour-responsive antibody–drug conjugates.
Document Type: article in journal/newspaper
Language: English
DOI: 10.1039/d5sc06664f
Availability: https://doi.org/10.1039/d5sc06664f; http://pubs.rsc.org/en/content/articlepdf/2026/SC/D5SC06664F
Rights: http://creativecommons.org/licenses/by/3.0/
Accession Number: edsbas.6905F9C7
Database: BASE