| Title: |
Genome-wide association study identifies two susceptibility loci for osteosarcoma |
| Authors: |
Savage, SA; Mirabello, L; Wang, Z; Gastier-Foster, JM; Gorlick, R; Khanna, C; Flanagan, AM; Tirabosco, R; Andrulis, IL; Wunder, JS; Gokgoz, N; Patiño-Garcia, A; Sierrasesúmaga, L; Lecanda, F; Kurucu, N; Ilhan, IE; Sari, N; Serra, M; Hattinger, C; Picci, P; Spector, LG; Barkauskas, DA; Marina, N; De Toledo, SRC; Petrilli, AS; Amary, MF; Halai, D; Thomas, DM; Douglass, C; Meltzer, PS; Jacobs, K; Chung, CC; Berndt, SI; Purdue, MP; Caporaso, NE; Tucker, M; Rothman, N; Landi, MT; Silverman, DT; Kraft, P; Hunter, DJ; Malats, N; Kogevinas, M; Wacholder, S; Troisi, R; Helman, L; Fraumeni, JF; Yeager, M; Hoover, RN; Chanock, SJ |
| Publisher Information: |
NATURE PUBLISHING GROUP |
| Publication Year: |
2013 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10⁻⁹) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10⁻⁸ and 2.9 × 10⁻⁷, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1061-4036 |
| Relation: |
pii: ng.2645; https://hdl.handle.net/11343/268793 |
| Availability: |
https://hdl.handle.net/11343/268793 |
| Accession Number: |
edsbas.69102670 |
| Database: |
BASE |