| Title: |
Functional analysis of DNA methylation markers and cfDNA-based methRisk performance. |
| Authors: |
Ran Hu; Benjamin Tran; Shuo Li; Mary L. Stackpole; Weihua Zeng; Yonggang Zhou; Andrew Melehy; Saeed Sadeghi; Richard S. Finn; Xianghong Jasmine Zhou; Wenyuan Li; Vatche G. Agopian |
| Publication Year: |
2025 |
| Subject Terms: |
Biophysics; Cell Biology; Genetics; Biotechnology; Developmental Biology; Cancer; Infectious Diseases; Virology; Mathematical Sciences not elsewhere classified; staging significantly improved; radiographic imaging features; peripheral blood draw; multivariate cox model; improve treatment decision; early cancer diagnosis; discriminating patient outcomes; critical unmet need; cancer genome atlas; based risk score; 80 &# 8211; 68 &# 8211; pilot study demonstrating; new prognostic biomarkers; identified 158 hcc; 377 hcc tumors; noninvasive prognostic assessments; potential clinical utility; plasma cfdna samples; hepatocellular carcinoma based; stratify hcc patients |
| Description: |
(A) Composition of markers in terms of genome annotation. (B) KEGG pathway enrichment analysis, and GO enrichment analysis of biological pathways associated with the methylation marker-related genes. The bar charts show the top 10 enriched terms ranked by p-value. (C) Time-dependent AUCs for individual features predicting 3-year survival in the patient cohort with plasma samples. Error bars represent the 95% confidence intervals. The sample size (n) is annotated to the right of the error bar. |
| Document Type: |
still image |
| Language: |
unknown |
| DOI: |
10.1371/journal.pone.0321736.g002 |
| Availability: |
https://doi.org/10.1371/journal.pone.0321736.g002; https://figshare.com/articles/figure/Functional_analysis_of_DNA_methylation_markers_and_cfDNA-based_methRisk_performance_/28872248 |
| Rights: |
CC BY 4.0 |
| Accession Number: |
edsbas.692A46DE |
| Database: |
BASE |