| Title: |
Sex-based differences in myocardial infarction-induced kidney damage following cigarette smoking exposure: more renal protection in premenopausal female mice |
| Authors: |
Habeichi, Nada J; Mroueh, Ali; Kaplan, Abdullah; Ghali, Rana; Al-Awassi, Hiam; Tannous, Cynthia; Husari, Ahmad; Jurjus, Abdo; Altara, Raffaele; Booz, George W.; El-Yazbi, Ahmed; Zouein, Fouad A. |
| Source: |
0144-8463. |
| Publisher Information: |
Kluwer Academic/Plenum Publishers |
| Publication Year: |
2020 |
| Collection: |
Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| Description: |
The impact of cigarette smoking (CS) on kidney homeostasis in the presence of myocardial infarction (MI) in both males and females remains poorly elucidated. C57BL6/J mice were exposed to 2 weeks of CS prior to MI induction followed by 1 week of CS exposure in order to investigate the impact of CS on kidney damage in the presence of MI. Cardiac hemodynamic analysis revealed a significant decrease in ejection fraction (EF) in CS-exposed MI male mice when compared with the relative female subjects, whereas cardiac output (CO) comparably decreased in CS-exposed MI mice of both sexes. Kidney structural alterations, including glomerular retraction, proximal convoluted tubule (PCT) cross-sectional area, and total renal fibrosis were more pronounced in CS-exposed MI male mice when compared with the relative female group. Although renal reactive oxygen species (ROS) generation and glomerular DNA fragmentation significantly increased to the same extent in CS-exposed MI mice of both sexes, alpha-smooth muscle actin (α-SMA) and connective tissue growth factor (CTGF) significantly increased in CS-exposed MI male mice, only. Metabolically, nicotinamide phosphoribosyltransferase (NAMPT) and nicotinamide riboside-1 (NMRK-1) substantially increased in CS-exposed MI female mice only, whereas sirtuin (SIRT)-1 and SIRT-3 substantially decreased in CS-exposed MI male mice compared with their relative female group. Additionally, renal NAD levels significantly decreased only in CS-exposed MI male mice. In conclusion, MI female mice exhibited pronounced renal protection following CS when compared with the relative male groups. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://hdl.handle.net/10852/81292; 1845281; Bioscience Reports; 40; BSR20193229.; https://doi.org/10.1042/BSR20193229 |
| DOI: |
10.1042/BSR20193229 |
| Availability: |
http://hdl.handle.net/10852/81292; http://urn.nb.no/URN:NBN:no-84381; https://doi.org/10.1042/BSR20193229 |
| Rights: |
Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.6930F089 |
| Database: |
BASE |