| Title: |
A coumarin derivative-Cu 2+ complex-based fluorescent chemosensor for detection of biothiols |
| Authors: |
NK Hien; M Van Bay; PD Tran; NT Khanh; ND Luyen; Quan Van Vo; DU Van; PC Nam; DT Quang |
| Publication Year: |
2020 |
| Collection: |
La Trobe University (Melbourne): Figshare |
| Subject Terms: |
Science & Technology; Physical Sciences; Chemistry; Multidisciplinary; STABILITY-CONSTANTS; SELECTIVE DETECTION; BENCHMARK SET; AMINO-ACIDS; COMPLEXES; PROBE; GLUTATHIONE; CYSTEINE; IONS; HG2+ |
| Description: |
© The Royal Society of Chemistry. Herein, a novel fluorescent sensor has been developed for the detection of biothiols based on theoretical calculations of the stability constant of the complex between a Cu2+ ion and (E)-3-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-7-(diethylamino) coumarin (BDC) as a fluorescent ligand. In this study, on the basis of density functional theory method, the Gibbs free energy of ligand-exchange reaction and the solvation model were carried out using thermodynamic cycles. The obtained results are in good agreement with the experimental data. The BDC-Cu2+ complex can be used as a fluorescent sensor for the detection of biothiols in the presence of non-thiol containing amino acids, with a detection limit for cysteine at 0.3 μM. Moreover, theoretical calculations of excited states were used to elucidate variations in the fluorescence properties. The computed results show that the excited doublet states D2 and D1 are dark doublet states, which quench the fluorescence of the complex. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.26181/5fb74fe1f1237 |
| Availability: |
https://doi.org/10.26181/5fb74fe1f1237; https://figshare.com/articles/journal_contribution/A_coumarin_derivative-Cu_sup_2_sup_complex-based_fluorescent_chemosensor_for_detection_of_biothiols/13264604 |
| Rights: |
CC BY 4.0 |
| Accession Number: |
edsbas.6948F2A0 |
| Database: |
BASE |