| Title: |
Towards the WHO target of zero childhood tuberculosis deaths: an analysis of mortality in 13 locations in Africa and Asia. |
| Authors: |
Russell, GK; Merle, CS; Cooke, GS; Casas, EC; Silveira da Fonseca, M; du Cros, P |
| Publisher Information: |
International Union Against Tuberculosis and Lung Disease |
| Publication Year: |
2013 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
SETTING: Achieving the World Health Organization (WHO) target of zero paediatric tuberculosis (TB) deaths will require an understanding of the underlying risk factors for mortality. OBJECTIVE: To identify risk factors for mortality and assess the impact of human immunodeficiency virus (HIV) testing during anti-tuberculosis treatment in children in 13 TB-HIV programmes run by Médecins Sans Frontières. DESIGN: In a retrospective cohort study, we recorded mortality and analysed risk factors using descriptive statistics and logistic regression. Diagnosis was based on WHO algorithm and smear microscopy. RESULTS: A total of 2451 children (mean age 5.2 years, SD 3.9) were treated for TB. Half (51.0%) lived in Asia, the remainder in sub-Saharan Africa; 56.0% had pulmonary TB; 6.4% were diagnosed using smear microscopy; 211 (8.6%) died. Of 1513 children tested for HIV, 935 (61.8%) were positive; 120 (12.8%) died compared with 30/578 (5.2%) HIV-negative children. Risk factors included being HIV-positive (OR 2.6, 95%CI 1.6-4.2), age |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| ISSN: |
1027-3719 |
| Relation: |
Russell, GK; Merle, CS ; Cooke, GS; Casas, EC; Silveira da Fonseca, M; and du Cros, P (2013) Towards the WHO target of zero childhood tuberculosis deaths: an analysis of mortality in 13 locations in Africa and Asia. The international journal of tuberculosis and lung disease, 17 (12). pp. 1518-1523. ISSN 1027-3719 DOI:10.5588/ijtld.13.0238 |
| DOI: |
10.5588/ijtld.13.0238 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/1462876/; https://doi.org/10.5588/ijtld.13.0238 |
| Accession Number: |
edsbas.6965BE69 |
| Database: |
BASE |