Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
| Title: | Large-scale gene-centric analysis identifies novel variants for coronary artery disease. |
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| Authors: | Butterworth AS; Braund PS; Farrall M; Hardwick RJ; Saleheen D; Peden JF; Soranzo N; Chambers JC; Sivapalaratnam S; Kleber ME; Keating B; Qasim A; Klopp N; Erdmann J; Assimes TL; Ball SG; Balmforth AJ; Barnes TA; Basart H; Baumert J; Bezzina CR; Boerwinkle E; Boehm BO; Brocheton J; Bugert P; Cambien F; Clarke R; Codd V; Collins R; Couper D; Cupples LA; de Jong JS; Diemert P; Ejebe K; Elbers CC; Elliott P; Fornage M; Franzosi MG; Frossard P; Garner S; Goel A; Goodall AH; Hengstenberg C; Hunt SE; Kastelein JJ; Klungel OH; Klüter H; Koch K; König IR; Kooner AS; Laaksonen R; Lathrop M; Li M; Liu K; McPherson R; Musameh MD; Musani S; Nelson CP; O'Donnell CJ; Ongen H; Papanicolaou G; Peters A; Peters BJ; Potter S; Psaty BM; Qu L; Rader DJ; Rasheed A; Rice C; Scott J; Seedorf U; Sehmi JS; Sotoodehnia N; Stark K; Stephens J; van der Schoot CE; van der Schouw YT; Thorsteinsdottir U; Tomaszewski M; van der Harst P; Vasan RS; Wilde AA; Willenborg C; Winkelmann BR; Zaidi M; Zhang W; Ziegler A; de Bakker PI; Koenig W; Mätz W; Trip MD; Reilly MP; Kathiresan S; Schunkert H; Hamsten A; Hall AS; Kooner JS; Thompson SG; Thompson JR; Deloukas P; Ouwehand WH; Watkins H; Danesh J; Samani NJ; Barnes T; Rafelt S; Bruinsma N; Dekker LR; Henriques JP; Koch KT; de Winter RJ; Alings M; Allaart CF; Gorgels AP; Verheugt FW; Mueller M; Meisinger C; DerOhannessian S; Mehta NN; Ferguson J; Hakonarson H; Matthai W; Wilensky R; Hopewell JC; Parish S; Linksted P; Notman J; Gonzalez H; Young A; Ostley T; Munday A; Goodwin N; Verdon V; Shah S; Cobb L; Edwards C; Mathews C; Gunter R; Benham J; Davies C; Cobb M; Crowther J; Richards A; Silver M; Tochlin S; Mozley S; Clark S; Radley M; Kourellias K; Silveira A; Söderholm B; Olsson P; Barlera S; Tognoni G; Rust S; Assmann G; Heath S; Zelenika D; Gut I; Green F; Peden J; Aly A; Anner K; Björklund K; Blomgren G; Cederschiöld B; Danell Toverud K; Eriksson P; Grundstedt U; Heinonen M; Hellénius ML; van't Hooft F; Husman K; Lagercrantz J; Larsson A; Larsson M; Mossfeldt M; Mälarstig A; Olsson G; Sabater Lleal M; Sennblad B; Strawbridge R; Öhrvik J; Zaman KS; Mallick NH; Azhar M; Samad A; Ishaq M; Shah N; Samuel M; Reilly M; Holm H; Preuss M; Stewart AF; Barbalic M; Gieger C; Absher D; Aherrahrou Z; Allayee H; Altshuler D; Anand S; Andersen K; Anderson JL; Ardissino D; Becker LC; Becker DM; Berger K; Bis JC; Boekholdt SM; Brown MJ; Burnett MS; Buysschaert I; Carlquist JF; Chen L; Davies RW; Dedoussis G; Dehghan A; Demissie S; Devaney J; Do R; Doering A; El Mokhtari NE; Ellis SG; Elosua R; Engert JC; Epstein S; de Faire U; Fischer M; Folsom AR; Freyer J; Gigante B; Girelli D; Gretarsdottir S; Gudnason V; Gulcher JR; Tennstedt S; Halperin E; Hammond N; Hazen SL; Hofman A; Horne BD; Illig T; Iribarren C; Jones GT; Jukema JW; Kaiser MA; Kaplan LM; Khaw KT; Knowles JW; Kolovou G; Kong A; Lambrechts D; Leander K; Lieb W; Lettre G; Loley C; Lotery AJ; Mannucci PM; Maouche S; MARTINELLI, Nicola; McKeown PP; Meitinger T; Melander O; Merlini PA; Mooser V; Morgan T; Mühleisen TW; Muhlestein JB; Musunuru K; Nahrstaedt J; Nöthen MM; Peyvandi F; Patel RS; Patterson CC; Quyyumi AA; Rallidis LS; Roosendaal FR; Rubin D; Salomaa V; Sampietro ML; Sandhu MS; Schadt E; Schäfer A; Schillert A; Schreiber S; Schrezenmeir J; Schwartz SM; Siscovick DS; Sivananthan M; Smith AV; Smith TB; Snoep JD; Spertus JA; Stefansson K; Stirrups K; Stoll M; Tang WH; Thorgeirsson G; Thorleifsson G; Uitterlinden AG; van Rij AM; Voight BF; Wareham NJ; AWells G; Wichmann HE; Witteman JC; Wright BJ; Ye S; Quertermous T; März W; Blankenberg S; Roberts R; Onland Moret NC; van Setten J; Verschuren WM; Boer JM; Wijmenga C; Hofker MH; Maitland van der Zee AH; de Boer A; Grobbee DE; Attwood T; Belz S; Braund P; Cooper J; Crisp Hihn A; Foad N; Gracey J; Gray E; Gwilliams R; Heimerl S; Jolley J; Krishnan U; Lloyd Jones H; Lugauer I; Lundmark P; Moore JS; Muir D; Murray E; Neudert J; Niblett D; O'Leary K; Pollard H; Rankin A; Rice CM; Sager H; Sambrook J; Schmitz G; Scholz M; Schroeder L; Syvannen AC; Wallace C.; OLIVIERI, Oliviero |
| Contributors: | Butterworth, A; Braund, P; Farrall, M; Hardwick, Rj; Saleheen, D; Peden, Jf; Soranzo, N; Chambers, Jc; Sivapalaratnam, S; Kleber, Me; Keating, B; Qasim, A; Klopp, N; Erdmann, J; Assimes, Tl; Ball, Sg; Balmforth, Aj; Barnes, Ta; Basart, H; Baumert, J; Bezzina, Cr; Boerwinkle, E; Boehm, Bo; Brocheton, J; Bugert, P; Cambien, F; Clarke, R; Codd, V; Collins, R; Couper, D; Cupples, La; de Jong, J; Diemert, P; Ejebe, K; Elbers, Cc; Elliott, P; Fornage, M; Franzosi, Mg; Frossard, P; Garner, S; Goel, A; Goodall, Ah; Hengstenberg, C; Hunt, Se; Kastelein, Jj; Klungel, Oh; Klüter, H; Koch, K; König, Ir; Kooner, A; Laaksonen, R; Lathrop, M; Li, M; Liu, K; Mcpherson, R; Musameh, Md; Musani, S; Nelson, Cp; O'Donnell, Cj; Ongen, H; Papanicolaou, G; Peters, A; Peters, Bj; Potter, S; Psaty, Bm; Qu, L; Rader, Dj; Rasheed, A; Rice, C; Scott, J; Seedorf, U; Sehmi, J; Sotoodehnia, N; Stark, K; Stephens, J; van der Schoot, Ce; van der Schouw, Yt; Thorsteinsdottir, U; Tomaszewski, M; van der Harst, P; Vasan, R; Wilde, Aa; Willenborg, C; Winkelmann, Br; Zaidi, M; Zhang, W; Ziegler, A; de Bakker, Pi; Koenig, W; Mätz, W; Trip, Md; Reilly, Mp; Kathiresan, S; Schunkert, H; Hamsten, A; Hall, A; Kooner, J; Thompson, Sg; Thompson, Jr; Deloukas, P |
| Publication Year: | 2011 |
| Collection: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| Subject Terms: | coronary artery disease; genetics |
| Description: | Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including analysis of many uncommon and functional variants. We examined 49,094 genetic variants in ∼2,100 genes of cardiovascular relevance, using a customised gene array in 15,596 CAD cases and 34,992 controls (11,202 cases and 30,733 controls of European descent; 4,394 cases and 4,259 controls of South Asian origin). We attempted to replicate putative novel associations in an additional 17,121 CAD cases and 40,473 controls. Potential mechanisms through which the novel variants could affect CAD risk were explored through association tests with vascular risk factors and gene expression. We confirmed associations of several previously known CAD susceptibility loci (eg, 9p21.3:p |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000295419100015; ispartofseries:2011 Sep;7(9):e1002260. Epub 2011 Sep 22.; volume:7(9); issue:Epub 2011 Sep 22.; firstpage:1; lastpage:14; numberofpages:14; journal:PLOS GENETICS; https://hdl.handle.net/11562/373822 |
| Availability: | https://hdl.handle.net/11562/373822 |
| Accession Number: | edsbas.69978C9C |
| Database: | BASE |