| Title: |
Medical Care for Tuberculosis-HIV-Coinfected Patients in Russia with Respect to a Changeable Patients’ Structure |
| Authors: |
Olga P. Frolova; Olga V. Butylchenko; Patimat G. Gadzhieva; Margarita Yu. Timofeeva; Valeria A. Basangova; Vladislava O. Petrova; Inna A. Fadeeva; Maria I. Kashutina; Nadezhda N. Zabroda; Artem A. Basov; Elena V. Belova; Yury V. Zhernov; Oleg V. Mitrokhin; Inga I. Enilenis; Lyudmila P. Severova |
| Source: |
Tropical Medicine and Infectious Disease, Vol 7, Iss 86, p 86 (2022) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2022 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
HIV; AIDS; tuberculosis; drug resistance; social maladaptation; Medicine |
| Description: |
To date, tuberculosis (TB) remains the primary cause of mortality in human immunodeficiency virus (HIV) patients in Russia. Since the beginning of 2000, a sharp change in the HIV patients’ structure, to the main known risk factors for HIV infection has taken place in Russia. The transmission of HIV through injectable drug use has begun to decline significantly, giving way to the prevalence of sexual HIV transmission today. These changes may require adjustments to organizational approaches to anti-TB care and the treatment of HIV-positive patients. Our study is aimed at identifying changes in TB-HIV coinfection patients’ structures in 2019 compared to 2000. Based on the results obtained, our goal was to point out the parameters that need to be taken into account when developing approaches to improve the organization of TB control care for people with HIV infection. We have carried out a cross-sectional, retrospective, epidemiological study using government TB registry data from four regions in two federal districts of Russia in 2019. The case histories of 2265 patients from two regions with high HIV prevalence, which are part of the Siberian Federal District of Russia, and 89 patient histories from two regions of low HIV prevalence, which are part of the Central Federal District of Russia, were analyzed. We found that parenteral transmission (69.4%) remains the primary route of HIV transmission among the TB-HIV coinfected. The unemployed of working age without disability account for 80.2% of all coinfected people, while the formerly incarcerated account for 53.7% and the homeless account for 4.1%. Those with primary multidrug-resistant TB (MDR-TB) comprise 56.2% of HIV-TB patients. When comparing the incidence of coinfection with HIV among TB patients, statistically significant differences were obtained. Thus, the chances of coinfection increased by 4.33 times among people with active TB (95% CI: 2.31; 8.12), by 2.97 times among people with MDR-TB (95% CI: 1.66; 5.32), by 5.2 times in people with advanced ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/2414-6366/7/6/86; https://doaj.org/toc/2414-6366; https://doaj.org/article/e7a3177356aa4b6399b06d01f6f8c633 |
| DOI: |
10.3390/tropicalmed7060086 |
| Availability: |
https://doi.org/10.3390/tropicalmed7060086; https://doaj.org/article/e7a3177356aa4b6399b06d01f6f8c633 |
| Accession Number: |
edsbas.69D1EB5A |
| Database: |
BASE |