Additional file 3 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
| Title: | Additional file 3 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
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| Authors: | Benjamin Lin; Abigail K. Shelton; Erin Smithberger; Julia Ziebro; Kasey R. Skinner; Ryan E. Bash; Richard Kirkman; Allie Stamper; Madison Butler; Alex Flores; Steven P. Angus; Michael P. East; Timothy F. Cloughesy; David A. Nathanson; Michael E. Berens; Jann N. Sarkaria; Zev A. Binder; Donald M. O’Rourke; Timothy C. Howton; Brittany N. Lasseigne; Christopher D. Willey; Gary L. Johnson; Anita B. Hjelmeland; Frank B. Furnari; C. Ryan Miller |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Biochemistry; Medicine; Genetics; Pharmacology; Biotechnology; Marine Biology; Cancer; Hematology; Virology; Computational Biology; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; EGFR; Glioblastoma; Synthetic lethality; Kinome rewiring; Upfront combinatorial therapy |
| Description: | Supplementary Material 3: Fig. S2 EGFRvIII (hEGFR) overexpression reprograms the receptor kinase transcriptome. Unsupervised hierarchical clustering heatmaps (AB) and volcano plots (CD) of DE receptor kinases at the mRNA level in both full (A) and starved (B) culture conditions show consistent downregulation in CEv3 (C) and C (D) cells. Full and starved serum cultures are denoted FS and SS, respectively |
| Document Type: | still image |
| Language: | unknown |
| DOI: | 10.6084/m9.figshare.29431972.v1 |
| Availability: | https://doi.org/10.6084/m9.figshare.29431972.v1; https://figshare.com/articles/figure/Additional_file_3_of_Identifying_and_exploiting_combinatorial_synthetic_lethality_by_characterizing_adaptive_kinome_rewiring_of_EGFRvIII-driven_glioblastoma/29431972 |
| Rights: | CC BY |
| Accession Number: | edsbas.6A00A12E |
| Database: | BASE |