| Title: |
Synthesis and Tactics of Organic Synthesis of 6-(5-mercapto-4R-4H-1,2,4-triazol-3-YL)pyrimidine-2,4(1H,3H)-dione Derivatives |
| Authors: |
Yuriy Karpenko |
| Source: |
Chemistry Proceedings ; Volume 18 ; Issue 1 ; Pages: 46 |
| Publisher Information: |
Multidisciplinary Digital Publishing Institute |
| Publication Year: |
2025 |
| Collection: |
MDPI Open Access Publishing |
| Subject Terms: |
pyrimidine-2,4(1 H ,3 H )-dione; 1,2,4-triazole; orotic acid; cyclocondensation |
| Description: |
Synthesis of 6-(5-mercapto-4R-4H-1,2,4-triazol-3-yl)pyrimidine-2,4(1H,3H)-dione derivatives offer a versatile platform for the development of new heterocyclic compounds. These molecules combine the biologically relevant 1,2,4-triazole ring, known for its antimicrobial and antioxidant properties, with a pyrimidine-2,4-dione core structurally related to vitamin B13 (orotic acid), essential in nucleic acid metabolism. This dual structure opens a wide spectrum of synthetic possibilities, particularly in heterocyclization reactions. The synthesis usually begins with the formation of the triazole ring through cyclocondensation of thiosemicarbazides with appropriate carbonyl precursors, followed by functionalization of the thiol group via S-alkylation or S-arylation. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
English |
| DOI: |
10.3390/ecsoc-29-26848 |
| Availability: |
https://doi.org/10.3390/ecsoc-29-26848 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.6A2B61A3 |
| Database: |
BASE |