A prognostic model to predict survival after 6 months of ruxolitinib in patients with myelofibrosis
| Title: | A prognostic model to predict survival after 6 months of ruxolitinib in patients with myelofibrosis |
|---|---|
| Authors: | Maffioli M; Mora B; Ball S; Iurlo A; Elli EM; Finazzi MC; Polverelli N; Rumi E; Caramella M; Carraro MC; D'Adda M; Molteni A; Sissa C; Lunghi F; Vismara A; Ubezio M; Guidetti A; Caberlon S; Anghilieri M; Komrokji R; Cattaneo D; Della Porta MG; Giorgino T; Bertù L; Brociner M; Kuykendall A; Passamonti F. |
| Contributors: | Maffioli, M; Mora, B; Ball, S; Iurlo, A; Elli, Em; Finazzi, Mc; Polverelli, N; Rumi, E; Caramella, M; Carraro, Mc; D'Adda, M; Molteni, A; Sissa, C; Lunghi, F; Vismara, A; Ubezio, M; Guidetti, A; Caberlon, S; Anghilieri, M; Komrokji, R; Cattaneo, D; Della Porta, Mg; Giorgino, T; Bertù, L; Brociner, M; Kuykendall, A; Passamonti, F. |
| Publication Year: | 2022 |
| Collection: | IRIS UNIPV (Università degli studi di Pavia) |
| Subject Terms: | ruxolitinib; prognosis; survival |
| Description: | Ruxolitinib (RUX) is extensively used in myelofibrosis (MF). Despite its early efficacy, most patients lose response over time and, after discontinuation, have a worse overall survival (OS). Currently, response criteria able to predict OS in RUX-treated patients are lacking, leading to uncertainty regarding the switch to second-line treatments. In this study, we investigated predictors of survival collected after 6 months of RUX in 209 MF patients participating in the real-world ambispective observational RUXOREL-MF study (NCT03959371). Multivariable analysis identified the following risk factors: (1) RUX dose |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35130339; info:eu-repo/semantics/altIdentifier/wos/WOS:000791841500005; volume:6; issue:6; firstpage:1855; lastpage:1864; numberofpages:10; journal:BLOOD ADVANCES; https://hdl.handle.net/11571/1477240; https://pubmed.ncbi.nlm.nih.gov/35130339/ |
| Availability: | https://hdl.handle.net/11571/1477240; https://pubmed.ncbi.nlm.nih.gov/35130339/ |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.6A5DFDFC |
| Database: | BASE |