Daily digital biomarkers in the follow-up and clustering of patients with asthma
| Title: | Daily digital biomarkers in the follow-up and clustering of patients with asthma |
|---|---|
| Authors: | Sousa-Pinto B.; Schleich F.; Louis G.; Gemicioglu B.; Kvedariene V.; Regateiro F. S.; Chaves Loureiro C.; Taborda-Barata L.; Amaral R.; Anto J. M.; Bedbrook A.; Czarlewski W.; Ansotegui I. J.; Bergmann K. -C.; Bonini M.; Bossios A.; Boulet L. -P.; Braido F.; Brightling C.; Brusselle G.; Brussino L.; Canonica G. W.; Cruz A. A.; Haahtela T.; Heaney L. G.; Hyland M.; Ivancevich J. C.; Klimek L.; Kulus M.; Kuna P.; Kupczyk M.; Larenas-Linnemann D. E.; Makris M.; Marques-Cruz M.; Gil-Mata S.; Morais-Almeida M.; Niedoszytko M.; Ollert M.; Papadopoulos N. G.; Patella V.; Pfaar O.; Porsbjerg C.; Puggioni F.; Quirce S.; Robalo Cordeiro C.; Roche N.; Samolinski B.; Sastre J.; Scichilone N.; Skrgat S.; Toppila-Salmi S.; Usmani O. S.; Valiulis A.; Gradauskiene B.; Vardaloglu Koyuncu I.; Ventura M. T.; Vieira R. J.; Yorgancioglu A.; Fonseca J. A.; Zuberbier T.; Petre B.; Louis R.; Bousquet J. |
| Contributors: | Sousa-Pinto, B.; Schleich, F.; Louis, G.; Gemicioglu, B.; Kvedariene, V.; Regateiro, F.S.; Chaves Loureiro, C.; Taborda-Barata, L.; Amaral, R.; Anto, J.M.; Bedbrook, A.; Czarlewski, W.; Ansotegui, I.J.; Bergmann, K.-.; Bonini, M.; Bossios, A.; Boulet, L.-.; Braido, F.; Brightling, C.; Brusselle, G.; Brussino, L.; Canonica, G.W.; Cruz, A.A.; Haahtela, T.; Heaney, L.G.; Hyland, M.; Ivancevich, J.C.; Klimek, L.; Kulus, M.; Kuna, P.; Kupczyk, M.; Larenas-Linnemann, D.E.; Makris, M.; Marques-Cruz, M.; Gil-Mata, S.; Morais-Almeida, M.; Niedoszytko, M.; Ollert, M.; Papadopoulos, N.G.; Patella, V.; Pfaar, O.; Porsbjerg, C.; Puggioni, F.; Quirce, S.; Robalo Cordeiro, C.; Roche, N.; Samolinski, B.; Sastre, J.; Scichilone, N.; Skrgat, S.; Toppila-Salmi, S.; Usmani, O.S.; Valiulis, A.; Gradauskiene, B.; Vardaloglu Koyuncu, I.; Ventura, M.T.; Vieira, R.J.; Yorgancioglu, A.; Fonseca, J.A.; Zuberbier, T.; Petre, B.; Louis, R.; Bousquet, J. |
| Publisher Information: | Taylor and Francis Ltd. |
| Publication Year: | 2025 |
| Collection: | IRIS Università degli Studi di Palermo |
| Subject Terms: | Asthma; electronic symptom-medication score; inhaled corticosteroids; mHealth; PROMs; Settore MEDS-07/A - Malattie dell'apparato respiratorio |
| Description: | Background and Research question: We aimed to assess whether levels of digital biomarkers can reflect monthly patterns of asthma control Study design and methods: We performed a longitudinal study on patients with asthma and comorbid rhinitis who filled ≥26 days of data in a month in the MASK-air® app and who reported at least 1 day of treatment with an inhaled corticosteroid with or without a long-acting β2-agonist (ICS ± LABA). We applied k-means cluster analysis to define clusters of months according to daily asthma control and medication use. Clusters were compared using digital biomarkers (visual analogue scale [VAS] on asthma symptoms and electronic daily asthma control score [e-DASTHMA]). We compared patients who did not switch with patients who switched their ICS ± LABA. Results: We assessed 243 patients and 1358 months. We identified three clusters of poor asthma control despite high ICS ± LABA adherence, one cluster of poor asthma control and poor ICS ± LABA adherence, one cluster of good asthma control and high ICS ± LABA adherence and one cluster of good asthma control despite poor ICS ± LABA adherence. These clusters displayed relevant differences in VAS asthma and e-DASTHMA levels. Similar clusters were found in ‘non-switchers’ versus ‘switchers’. Conclusion: Levels of digital biomarkers reflect asthma control patterns and might be used to monitor patients with asthma. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40718903; info:eu-repo/semantics/altIdentifier/wos/WOS:001537606900001; volume:31; issue:1; numberofpages:14; journal:PULMONOLOGY; https://hdl.handle.net/10447/698891 |
| DOI: | 10.1080/25310429.2025.2532980 |
| Availability: | https://hdl.handle.net/10447/698891; https://doi.org/10.1080/25310429.2025.2532980 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.6A73B92E |
| Database: | BASE |