| Title: |
The alanine-serine-cysteine-1 (Asc-1) transporter controls glycine levels in the brain and is required for glycinergic inhibitory transmission |
| Authors: |
Safory, Hazem; Neame, Samah; Shulman, Yoav; Zubedat, Salman; Radzishevsky, Inna; Rosenberg, Dina; Sason, Hagit; Engelender, Simone; Avital, Avi; Huelsmann, Swen; Schiller, Jackie; Wolosker, Herman |
| Contributors: |
Safory, Hazem; Neame, Samah; Shulman, Yoav; Zubedat, Salman; Radzishevsky, Inna; Rosenberg, Dina; Sason, Hagit; Engelender, Simone; Avital, Avi; Huelsmann, Swen; Schiller, Jackie; Wolosker, Herman |
| Publisher Information: |
Wiley-blackwell |
| Publication Year: |
2015 |
| Collection: |
Georg-August-Universität Göttingen: GoeScholar |
| Description: |
Asc-1 (SLC7A10) is an amino acid transporter whose deletion causes neurological abnormalities and early postnatal death in mice. Using metabolomics and behavioral and electrophysiological methods, we demonstrate that Asc-1 knockout mice display a marked decrease in glycine levels in the brain and spinal cord along with impairment of glycinergic inhibitory transmission, and a hyperekplexia-like phenotype that is rescued by replenishing brain glycine. Asc-1 works as a glycine and L-serine transporter, and its transport activity is required for the subsequent conversion of L-serine into glycine invivo. Asc-1 is a novel regulator of glycine metabolism and a candidate for hyperekplexia disorders. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| Relation: |
000354131600011 |
| DOI: |
10.15252/embr.201439561 |
| Availability: |
https://resolver.sub.uni-goettingen.de/purl?gro-2/37246; https://doi.org/10.15252/embr.201439561 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.6A770366 |
| Database: |
BASE |