| Title: |
Clinical and genetic definition of serum bilirubin levels for the diagnosis of Gilbert syndrome and hypobilirubinemia |
| Authors: |
Poynard, Thierry; Deckmyn, Olivier; Peta, Valentina; Sakka, Mehdi; Lebray, Pascal; Moussalli, Joseph; Pais, Raluca; Housset, Chantal; Ratziu, Vlad; Pasmant, Eric; Thabut, Dominique |
| Source: |
Hepatology Communications ; volume 7, issue 10 ; ISSN 2471-254X |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2023 |
| Description: |
Background and Aims: Gilbert syndrome (GS) is genotypically predetermined by UGT1A1 *28 homozygosity in Europeans and is phenotypically defined by hyperbilirubinemia using total bilirubin (TB) cutoff ≥1mg/dL (17 μmol/L). The prevalence of illnesses associated with GS and hypobilirubinemia has never been studied prospectively. As TB varies with UGT1A1 *28 genotyping, sex, and age, we propose stratified definitions of TB reference intervals and report the prevalence of illnesses and adjusted 15 years survival. Methods: UK Biobank with apparently healthy liver participants (middle-aged, n=138,125) were analyzed after the exclusion of of nonhealthy individuals. The stratified TB was classified as GS when TB >90th centile; |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/hc9.0000000000000245 |
| DOI: |
10.1097/HC9.0000000000000245 |
| Availability: |
https://doi.org/10.1097/hc9.0000000000000245; https://journals.lww.com/10.1097/HC9.0000000000000245 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.6A7BF3DD |
| Database: |
BASE |