| Title: |
Design and synthesis of 2,6-disubstituted-8-amino imidazo[1,2a]pyridines, a promising privileged structure |
| Authors: |
Boulahjar, Rajaa; Rincon Arias, Angela; Bolteau, Raphael; Renault, Nicolas; Coevoet, Mathilde; Barczyk, Amélie; Duroux, Romain; Yous, Said; Melnyk, Patricia; Agouridas, Laurence |
| Contributors: |
CHU Lille; Inserm; Université de Lille; Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 JPArc; Lille Inflammation Research International Center - U 995 LIRIC |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
Amino-imidazopyridine; Privileged structure; Palladium-catalyzed coupling reaction; A(2A) receptor |
| Description: |
Imidazo[1,2a]pyridines have gained much interest in the field of medicinal chemistry research. In the aim of accessing new privileged structure, we decided to design and synthesize 8-aminated-imidazo[1,2a]pyridines substituted on positions 2 and 6. This scaffold, rarely found in the literature, was obtained via palladium-catalyzed coupling reactions (Suzuki reaction or N-hydroxysuccinimidyl activated ester method) and tested on adenosine receptor A2A ; 26 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream |
| Language: |
English |
| Relation: |
Bioorganic & medicinal chemistry; Bioorg. Med. Chem.; http://hdl.handle.net/20.500.12210/104897 |
| Availability: |
https://hdl.handle.net/20.500.12210/104897 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.6A83C262 |
| Database: |
BASE |