| Title: |
Does Antibody Avidity to Plasmodium falciparum Merozoite Antigens Increase with Age in Individuals Living in Malaria-Endemic Areas? |
| Authors: |
Tassi Yunga, Samuel; Bobbili, Naveen; Lloyd, Yukie M.; Antallan, Jovikka; Matsunaga, Masako; Quakyi, Isabella; Leke, Rose F. G.; Taylor, Diane Wallace |
| Contributors: |
Herbert, De'Broski R.; HHS | NIH | Fogarty International Center; HHS | NIH | National Institute of Allergy and Infectious Diseases; HHS | NIH | National Institute on Minority Health and Health Disparities |
| Source: |
Infection and Immunity ; volume 89, issue 6 ; ISSN 0019-9567 1098-5522 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2021 |
| Description: |
High-avidity antibodies (Abs) are acquired after a few Plasmodium falciparum infections in low transmission areas, but it remains unclear if Ab avidity to different merozoite antigens increases with age in individuals with persistent antigenemia and, if so, when a fully mature Ab response occurs. The study used plasma samples collected between 1996 and 1998 from 566 individuals aged 4 to 84 years in Simbok, Cameroon, where residents received an estimated 1.6 infectious mosquito bites/person/night. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/iai.00522-20 |
| DOI: |
10.1128/IAI.00522-20 |
| Availability: |
https://doi.org/10.1128/iai.00522-20; https://journals.asm.org/doi/pdf/10.1128/IAI.00522-20 |
| Rights: |
https://doi.org/10.1128/ASMCopyrightv2 ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.6AA5A98D |
| Database: |
BASE |