| Title: |
Potential of mid-infrared spectroscopy as a non-invasive diagnostic test in urine for endometrial or ovarian cancer |
| Authors: |
Paraskevaidi, Maria; Medeiros-De-morais, Camilo De lelis; Lima, Kassio M.G.; Ashton, Katherine; Stringfellow, Helen F.; Martin-Hirsch, Pierre L.; Martin, Francis L |
| Publisher Information: |
Royal Society of Chemistry (RSC) |
| Publication Year: |
2018 |
| Collection: |
University of Central Lancashire: CLOK - Central Lancashire Online Knowledge |
| Subject Terms: |
B700 - Nursing |
| Description: |
The current lack of an accurate, cost-effective and non-invasive test that would allow for screening and diagnosis of gynaecological carcinomas, such as endometrial and ovarian cancer, signals the necessity for alternative approaches. The potential of spectroscopic techniques in disease investigation and diagnosis has been previously demonstrated. Here, we used attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy to analyse urine samples from women with endometrial (n=10) and ovarian cancer (n=10), as well as from healthy individuals (n=10). After applying multivariate analysis and classification algorithms, biomarkers of disease were pointed out and high levels of accuracy were achieved for both endometrial (95% sensitivity, 100% specificity; accuracy: 95%) and ovarian cancer (100% sensitivity, 96.3% specificity; accuracy 100%). The efficacy of this approach, in combination with the non-invasive method for urine collection, suggest a potential diagnostic tool for endometrial and ovarian cancers. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0003-2654 |
| Relation: |
https://clok.uclan.ac.uk/id/eprint/23115/1/23115%202.%20Manuscript_clean%20version.pdf; Paraskevaidi, Maria, Medeiros-De-morais, Camilo De lelis orcid iconorcid:0000-0003-2573-787X , Lima, Kassio M.G., Ashton, Katherine, Stringfellow, Helen F., Martin-Hirsch, Pierre L. and Martin, Francis L orcid iconorcid:0000-0001-8562-4944 (2018) Potential of mid-infrared spectroscopy as a non-invasive diagnostic test in urine for endometrial or ovarian cancer. Analyst, 143 . pp. 3156-3163. ISSN 0003-2654 |
| DOI: |
10.1039/C8AN00027A |
| Availability: |
https://clok.uclan.ac.uk/id/eprint/23115/; https://clok.uclan.ac.uk/id/eprint/23115/1/23115%202.%20Manuscript_clean%20version.pdf; https://doi.org/10.1039/C8AN00027A |
| Rights: |
cc_by_nc_nd_4 |
| Accession Number: |
edsbas.6ABC73B9 |
| Database: |
BASE |