| Title: |
Defining the transmissible dose 50% for two pandemic influenza viruses in ferrets |
| Authors: |
Field, C. J.; Septer, K. M.; Patel, D. R.; Weaver, V. C.; Sim, D. G.; Restori, K. H.; Boni, M. F.; Sutton, T. C. |
| Contributors: |
Schoggins, John; National Institute of Allergy and Infectious Diseases; U.S. Department of Agriculture |
| Source: |
Journal of Virology ; ISSN 0022-538X 1098-5514 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2026 |
| Description: |
Ferrets are widely used to model airborne transmission of influenza viruses in humans. Airborne transmission is evaluated by infecting donor ferrets with a high virus dose and monitoring transmission to contact animals sharing the same airspace. Humans can be infected with a broad range of influenza virus doses. Therefore, we evaluated the relationship between inoculation dose and transmission for two pandemic influenza viruses in ferrets. Donor ferrets were inoculated with 10 0 to 10 6 tissue culture infectious dose 50 (TCID 50 ) of the 2009 pandemic H1N1 or 1968 pandemic H3N2 virus and were then paired with respiratory contacts. Using the proportion of donors that became infected across virus doses, we calculated the infectious dose 50 (ID 50 ). Subsequently, by comparing the proportion of contacts that became infected, we calculated the transmissible dose 50% (TD 50 ): the donor inoculation dose that resulted in transmission to 50% of contacts. For the 2009 pandemic H1N1 virus, the ID 50 and TD 50 were equivalent at |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/jvi.01635-25 |
| Availability: |
https://doi.org/10.1128/jvi.01635-25; https://journals.asm.org/doi/pdf/10.1128/jvi.01635-25 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.6AC836A9 |
| Database: |
BASE |