| Title: |
Amiodarone and thyroid status in refractary arrythmias |
| Authors: |
A. Piffanelli; D. Pelizzola; L. Ricci; L. Codecà; G. Giovannini; M. Giganti; V. Colamussi |
| Contributors: |
Piffanelli, A.; Pelizzola, D.; Ricci, L.; Codecà, L.; Giovannini, G.; Giganti, M.; Colamussi, V. |
| Publication Year: |
1988 |
| Collection: |
Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: |
Amiodarone; Arrhythmias; Thyroid status; Side effects |
| Description: |
Out of 20 subjects selected for refractory arrhythmias, amiodarone therapy (200mg/day) was efficacious in 85%. No statistically significant variations in electrocardiographic parameters (QTc) were observed; similarly, there was little evidence of side effects 1 year after initiation of treatment. These results were most likely due to the low daily dosage administered. We observed: 1) a significant increase in rT3 levels; 2) a decrease in TT3; 3) a uniform homeostasis of free fraction (FT3; FT4) These effects are all characteristic patterns of a "Low T3 Syndrome". The dosage of circulating amiodarone in 6 patients with borderline hormonal status (3 hyper-and 3 hypothyroidism) was not found to be an efficacious test for therapeutic monitoring. Identification of a statistically significant linear regression relationship between cumulative dose of amiodarone and rT3 levels may be a useful test in clinical practise for establishing more appropriate therapeutic dosages. Furthermore, it provides a guideline for threshold levels (maximum rT3=100-110ng/dl) which are in close association with several side effects. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/3398243; info:eu-repo/semantics/altIdentifier/wos/WOS:A1988M851300005; volume:29; issue:1; firstpage:45; lastpage:55; numberofpages:11; journal:JAPANESE HEART JOURNAL; https://hdl.handle.net/11392/1869743 |
| DOI: |
10.1536/ihj.29.45 |
| Availability: |
https://hdl.handle.net/11392/1869743; https://doi.org/10.1536/ihj.29.45; https://www.jstage.jst.go.jp/article/ihj1960/29/1/29_1_45/_article/-char/en; https://www.jstage.jst.go.jp/article/ihj1960/29/1/29_1_45/_pdf/-char/en |
| Rights: |
info:eu-repo/semantics/openAccess ; license:PUBBLICO - Pubblico con Copyright |
| Accession Number: |
edsbas.6AD4B5CE |
| Database: |
BASE |