| Title: |
Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent- Onset Cognitive Impairment |
| Authors: |
Furia A; Incensi A; Delprete C; Rizzo G; Bonvegna S; Piatti M; Olivola E; Ventruto F; Vacchiano V; Fileccia E; Cilia R; Modugno N; Liguori R; Donadio V. |
| Contributors: |
Furia, A; Incensi, A; Delprete, C; Rizzo, G; Bonvegna, S; Piatti, M; Olivola, E; Ventruto, F; Vacchiano, V; Fileccia, E; Cilia, R; Modugno, N; Liguori, R; Donadio, V. |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
dementia; immunofluorescence; Lewy bodie; skin biopsy; synucleinopathy |
| Description: |
Immunofluorescence for phosphorylated alpha- synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent- onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow- up clinical re- evaluation. Five patients fulfilled the Dementia with Lewy bodies diagnosis, all of them positive for skin phosphorylated alpha- synuclein. The remaining 14 patients were all negative. Skin tissue immunofluorescence may represent a promising technique in identifying synuclein pathology in recent- onset cognitive decline: larger cohorts are needed to confirm our preliminary data. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
volume:12; issue:9; firstpage:1919; lastpage:1925; numberofpages:7; journal:ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY; https://hdl.handle.net/11585/1049919 |
| Availability: |
https://hdl.handle.net/11585/1049919 |
| Accession Number: |
edsbas.6AEF67DA |
| Database: |
BASE |