| Title: |
Adolescent binge drinking disrupts normal trajectories of brain functional organization and personality maturation |
| Authors: |
Ruan, Hongtao; Zhou, Yunyi; Luo, Qiang; Robert, Gabriel H; Desrivières, Sylvane; Quinlan, Erin Burke; Liu, Zhaowen; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Flor, Herta; Frouin, Vincent; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Poustka, Luise; Hohmann, Sarah; Fröhner, Juliane H; Smolka, Michael N; Walter, Henrik; Whelan, Robert; Li, Fei; Schumann, Gunter; Feng, Jianfeng |
| Contributors: |
Fudan University Shanghai; Comportement et noyaux gris centraux = Behavior and Basal Ganglia Rennes; Université de Rennes (UR)-Université européenne de Bretagne - European University of Brittany (UEB)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Pontchaillou -Institut des Neurosciences Cliniques de Rennes = Institute of Clinical Neurosciences of Rennes (INCR); Institute of Psychiatry, Psychology & Neuroscience, King's College London; King‘s College London; Xidian University; Central Institute of Mental Health Mannheim; University Hospital Mannheim; Discipline of Psychiatry Dublin; School of Medicine Dublin; Trinity College Dublin-Trinity College Dublin; Service NEUROSPIN (NEUROSPIN); Université Paris-Saclay-Institut des Sciences du Vivant Frédéric JOLIOT (JOLIOT); Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA); University of Vermont Burlington; University of Nottingham, UK (UON); Charité - UniversitätsMedizin = Berlin University Medicine; Physikalisch-Technische Bundesanstalt Braunschweig (PTB); Neuroimagerie en psychiatrie (U1000); Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM); Universität Heidelberg Heidelberg = Heidelberg University; University Medical Center Göttingen (UMG); Technische Universität Dresden = Dresden University of Technology (TU Dresden); MR/N000390/1, Medical Research Council Canada; 20152234, Shanghai Municipal Education Commission; AERIAL 01EE1406A, Bundesministeriumfür Bildung und Forschung; ANR-12-SAMA-0004, ANR; Shanghai AI Platform for Diagnosis and Treatment of Brain Diseases; Fondation pour la Recherche Médicale; Assistance-Publique-Hôpitaux-de-Paris; 16/ERCD/3797, National Institutes of Health, Science Foundation Ireland; IDEX 2012, Université Paris-Sud; RO1 MH085772-01A1, U.S.A.; U54 EB020403, NIH; National Institute for Health Research; MR/N027558/1, BRIDGET; 81761128035, National Natural Science Foundation of China; Fondation de France; LSHM-CT- 2007-037286, European Commission; 2016-17, Project of Zhangjiang Hi-Tech District Management Committee, Shanghai; SFB 940/1, Deutsche Forschungsgemeinschaft; 695313, Horizon 2020 Framework Programme; Mission Interministérielle de Lutte Contre les Drogues et les Conduites Addictives; 17ZR1444400, Natural Science Foundation of Shanghai; Svenska Forskningsrådet Formas; 2018SHZDZX01, Shanghai Municipal Science and Technology; 602450, FP7; Zhangjiang Lab; 16JC1420402, Shanghai Science and Technology Innovation Plan; B18015, Higher Education Discipline Innovation Project; GDEK201709, Shanghai Municipal Commission of Health and Family Planning; 16CR2025B, Shanghai Shenkang Hospital Development Center; 17XD1403200, Shanghai Committee of Science and Technology; 2018YJRC03, Xinhua Hospital of Shanghai Jiao Tong University School of Medicine; PR-ST-0416-10004, ERANID; Institut National de la Santé et de la Recherche Médicale; 603016, MATRICS; 115300-2, Innovative Medicine Initiative Project EU-AIMS; Maudsley NHS Foundation Trust; 2018YFC0910503, National Basic Research Program of China (973 Program); King's College London; ANR-12-SAMA-0004,ADODEP,Dépression à l'Adolescence: Structure cérébrale et myélinisation(2012) |
| Source: |
ISSN: 2213-1582 ; Neuroimage-Clinical ; https://univ-rennes.hal.science/hal-02121078 ; Neuroimage-Clinical, 2019, 22, pp.101804. ⟨10.1016/j.nicl.2019.101804⟩. |
| Publisher Information: |
HAL CCSD; Elsevier |
| Publication Year: |
2019 |
| Collection: |
Université de Rennes 1: Publications scientifiques (HAL) |
| Subject Terms: |
Genome; Resting state; Personality; Adolescent; Binge drinking; Co-development; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Adolescent binge drinking has been associated with higher risks for the development of many health problems throughout the lifespan. Adolescents undergo multiple changes that involve the co-development processes of brain, personality and behavior; therefore, certain behavior, such as alcohol consumption, can have disruptive effects on both brain development and personality maturation. However, these effects remain unclear due to the scarcity of longitudinal studies. In the current study, we used multivariate approaches to explore discriminative features in brain functional architecture, personality traits, and genetic variants in 19-year-old individuals (n = 212). Taking advantage of a longitudinal design, we selected features that were more drastically altered in drinkers with an earlier onset of binge drinking. With the selected features, we trained a hierarchical model of support vector machines using a training sample (n = 139). Using an independent sample (n = 73), we tested the model and achieved a classification accuracy of 71.2%. We demonstrated longitudinally that after the onset of binge drinking the developmental trajectory of improvement in impulsivity slowed down. This study identified the disrupting effects of adolescent binge drinking on the developmental trajectories of both brain and personality. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/30991616; PUBMED: 30991616 |
| DOI: |
10.1016/j.nicl.2019.101804 |
| Availability: |
https://univ-rennes.hal.science/hal-02121078; https://univ-rennes.hal.science/hal-02121078v1/document; https://univ-rennes.hal.science/hal-02121078v1/file/hal-02121078.pdf; https://doi.org/10.1016/j.nicl.2019.101804 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.6AF33486 |
| Database: |
BASE |