| Title: |
Role of HLA-DP Polymorphisms on Chronicity and Disease Activity of Hepatitis B Infection in Southern Chinese |
| Authors: |
Wong, DKH; Watanabe, T; Tanaka, Y; Seto, WKW; Lee, CK; Fung, JYY; Lin, CK; Huang, FY; Lai, CL; Yuen, RMF |
| Publisher Information: |
//www.plosone.org/home.action; United States |
| Publication Year: |
2013 |
| Collection: |
University of Hong Kong: HKU Scholars Hub |
| Description: |
Background and Aims The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. Methods We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
PLoS ONE; PLoS One, 2013, v. 8 n. 6, p. e66920; e66920; 217273; WOS:000321223000043; PMC3692552; https://hub.hku.hk/handle/10722/185982 |
| DOI: |
10.1371/journal.pone.0066920 |
| Availability: |
https://hub.hku.hk/handle/10722/185982; https://doi.org/10.1371/journal.pone.0066920 |
| Rights: |
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
| Accession Number: |
edsbas.6B167596 |
| Database: |
BASE |