| Title: |
Optimizing Spray-Dried Porous Particles for High Dose Delivery with a Portable Dry Powder Inhaler |
| Authors: |
Yoen-Ju Son; Danforth P. Miller; Jeffry G. Weers |
| Source: |
Pharmaceutics, Vol 13, Iss 1528, p 1528 (2021) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
packing density; product density; small porous particles; corrugated particles; Pharmacy and materia medica; RS1-441 |
| Description: |
This manuscript critically reviews the design and delivery of spray-dried particles for the achievement of high total lung doses ( T L D ) with a portable dry powder inhaler. We introduce a new metric termed the product density, which is simply the T L D of a drug divided by the volume of the receptacle it is contained within. The product density is given by the product of three terms: the packing density (the mass of powder divided by the volume of the receptacle), the drug loading (the mass of drug divided by the mass of powder), and the aerosol performance (the T L D divided by the mass of drug). This manuscript discusses strategies for maximizing each of these terms. Spray drying at low drying rates with small amounts of a shell-forming excipient (low Peclet number) leads to the formation of higher density particles with high packing densities. This enables ultrahigh T L D (>100 mg of drug) to be achieved from a single receptacle. The emptying of powder from capsules is directly proportional to the mass of powder in the receptacle, requiring an inhaled volume of about 1 L for fill masses between 40 and 50 mg and up to 3.2 L for a fill mass of 150 mg. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/1999-4923/13/9/1528; https://doaj.org/toc/1999-4923; https://doaj.org/article/c047f1c2585045f2b911ba1109288267 |
| DOI: |
10.3390/pharmaceutics13091528 |
| Availability: |
https://doi.org/10.3390/pharmaceutics13091528; https://doaj.org/article/c047f1c2585045f2b911ba1109288267 |
| Accession Number: |
edsbas.6B1AD1B |
| Database: |
BASE |