| Title: |
Economic cost of strategic implementation approaches to increase uptake of digital therapeutics for substance use disorders in a large integrated health system |
| Authors: |
Wong, Edwin S.; Dorsey, Caitlin N.; Beatty, Tara C.; Bobb, Jennifer F.; Stefanik-Guizlo, Kelsey; Key, Dustin L.; Ramaprasan, Arvind; Idu, Abisola E.; Fortney, John C.; Mogk, Jessica; Palazzo, Lorella; Caldeiro, Ryan M.; King, Deborah; McWethy, Angela Garza; Glass, Joseph E. |
| Contributors: |
Simões de Almeida, Raquel; National Institute on Drug Abuse |
| Source: |
PLOS Digital Health ; volume 5, issue 1, page e0001145 ; ISSN 2767-3170 |
| Publisher Information: |
Public Library of Science (PLoS) |
| Publication Year: |
2026 |
| Collection: |
PLOS Publications (via CrossRef) |
| Description: |
Evidence-based digital therapeutics are a promising approach for the scale-up of substance use disorder (SUD) treatments. Despite demonstrated efficacy, utilization of digital therapeutics is low. Strategic implementation approaches have potential for increasing digital therapeutic use. Applicability to health systems depends, in part, on the economic costs. The objective of this study was to describe implementation and intervention costs of implementation strategies to increase uptake of an evidence-based digital treatment for SUD. We conducted an economic evaluation alongside a hybrid type III cluster-randomized trial within a large integrated health system. All clinics implemented a standard implementation (SI) strategy, and clinics were assigned using 2x2 factorial randomization to additionally receive practice facilitation (PF) and/or health coaching (HC). Implementation costs included the cost of time devoted to implementation activities and direct operating costs. Time devoted to implementation activities was ascertained through structured meeting logs and time use surveys. Operating costs were captured using project budget reports. Intervention costs included expenses for prescriptions and healthcare encounters related to the digital therapeutic, measured using electronic health record data. Univariate statistics were calculated for cost estimates with comparisons presented by trial arm, implementation activity, staff role and study month. Analyses were conducted from a health system perspective. Twenty-one primary care sites participated in the trial. Over the 50-month study period, the total cost of all implementation activities was $748,088. Implementation costs per clinic were highest in the SI + PF + HC arm ($48,029), followed by SI + HC ($36,544), SI + PF ($30,665) and SI alone ($24,774). Intervention costs were highest in the SI + PF + HC arm ($18,051), followed by SI + PF ($11,492), SI + HC ($967) and SI alone ($1,879). Findings from this study can guide health systems by informing the economic ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1371/journal.pdig.0001145 |
| Availability: |
https://doi.org/10.1371/journal.pdig.0001145; https://dx.plos.org/10.1371/journal.pdig.0001145 |
| Rights: |
https://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: |
edsbas.6B9F46 |
| Database: |
BASE |