| Title: |
Histologic comparison of the uterine pathologic effects of erythropoietin and U-74389G |
| Authors: |
Tsompos, Constantinos; Panoulis, Constantinos; Zografos, Constantinos; Zografos, GeorgeC; Papalois, Apostolos |
| Contributors: |
Elpen Pharmaceuticals Co SA Inc |
| Source: |
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan; Vol 13, No 1 (2026): FEBRUARY ; 2774-2318 ; 2407-0505 |
| Publisher Information: |
Universitas Muhammadiyah Semarang |
| Publication Year: |
2026 |
| Collection: |
E-Journal Universitas Muhammadiyah Semarang |
| Subject Terms: |
reperfusion; uterus; U-74389G; erythropoietin; ischemia |
| Description: |
Background: This manuscript compared the effects at uterine pathology (UP), after processing with either the drug erythropoietin hormone (Epo), or the lazaroid antioxidant agent (L) one U-74389G. This comparison was provided by outcomes of 2 preceding branches.Objective: Both studies estimated the effect, after each drug use in a planned uterine ischemia - reperfusion (UIR) mice experimental setting.Methods: Both principal experiment timepoints, the uterine histology was evaluated were the min 60th after reperfusion (A, C, E groups) and also the min 120th after reperfusion (B, D, F groups). Along, A & B groups were placebo, C & D groups were processed by Epo and E & F groups after the L process.Results: The one study-branch of Epo has presented a hardly significant recessing potency for the total UP within the “lesion-free” grade alteration by -0.0916667 [-0.1907629 - 0.0074296] (p-values = 0.0583). However, the other study-branch of U-74389G presented a respective non-significant accentuation of the total UP within the “lesion-free” grade alteration by 0.2229748 [-0.1376592 - 0.5836089] (p-value = 0.4940). Both branch studies got co-evaluated as they belong to a common experiment. Their outcome was that Epo seems to ameliorate the UP status, whereas L seems to deteriorate it; however, their discrepancy seems to be non-significant (p-value = 0.0677).Conclusion: There is a slight non-significant superiority of Epo than L in UIR pathology restoration (p-value = 0.0677), possibly useful in several clinical situations. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://jurnal.unimus.ac.id/index.php/APKKM/article/downloadSuppFile/19646/7081; https://jurnal.unimus.ac.id/index.php/APKKM/article/downloadSuppFile/19646/7082; https://jurnal.unimus.ac.id/index.php/APKKM/article/view/19646 |
| DOI: |
10.26714/magnamed.13.1.2026.%p |
| Availability: |
https://jurnal.unimus.ac.id/index.php/APKKM/article/view/19646; https://doi.org/10.26714/magnamed.13.1.2026.%p |
| Rights: |
Copyright (c) 2026 MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan ; https://creativecommons.org/licenses/by-nc-sa/4.0 |
| Accession Number: |
edsbas.6BB0777D |
| Database: |
BASE |