| Title: |
Preparing for Future Pandemics: Vaccine Effectiveness Against SARS-CoV-2 Variant in a High-Risk Hospital Environment—A Case Study From Vietnam |
| Authors: |
Nguyen, HT; Duong, LH; Pham, TQ; Dao, TH; Nguyen, KT; Ngu, ND; Tran, DN; Le, KT; Trinh, TS; Doorn, HRV; Vogt, F; Nguyen, KC |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
On 30 September 2021, Viet Duc University Hospital in Northern Vietnam, reported a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta outbreak, leading to an 18-day lockdown and repeated testing of all on-site individuals. At this time, SARS-CoV-2 was not yet circulating at scale among the general public and COVID-19 vaccination status varied among staff, patients, and caregivers. We estimated vaccine effectiveness (VE), attack rates (ARs), and adjusted risk ratios (aRRs) to identify factors associated with infection among infection-naïve patients, caregivers, and staff using multivariable regression analysis. Among 630 at-risk individuals, there were 131 (21%) polymerase chain reaction (PCR)-confirmed COVID-19 cases including three deaths. The overall VE was 78%. Hospital staff and people who were fully vaccinated had a significantly lower risk of SARS-CoV-2 infection (P < .05). Our analysis shows the importance of being fully vaccinated in reducing the risk of SARS-CoV-2 infection in hospital settings. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1177/10105395251360136 |
| DOI: |
10.1177/10105395251360136 |
| Availability: |
https://doi.org/10.1177/10105395251360136; https://ora.ox.ac.uk/objects/uuid:446aea6f-4009-4370-be97-9efec4da1c15 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution-NonCommercial (CC BY-NC) |
| Accession Number: |
edsbas.6BBB8234 |
| Database: |
BASE |