| Title: |
A GABAergic inhibitory component within the hippocampal commissural pathway |
| Authors: |
Ribak, CE; Seress, L; Peterson, GM; Seroogy, KB; Fallon, JH; Schmued, LC |
| Source: |
Journal of Neuroscience, vol 6, iss 12 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
1986 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3209 Neurosciences (for-2020); Neurosciences (rcdc); Animals (mesh); Axonal Transport (mesh); Female (mesh); Fluorescent Antibody Technique (mesh); Hippocampus (mesh); Histocytochemistry (mesh); Horseradish Peroxidase (mesh); Male (mesh); Microscopy; Electron (mesh); Neurons (mesh); Rats (mesh); Rats; Inbred Strains (mesh); Synapses (mesh); gamma-Aminobutyric Acid (mesh) |
| Time: |
3492 - 3498 |
| Description: |
Previous results from immunocytochemical and retrograde transport studies indicated that some GABAergic neurons in the hilus of the dentate gyrus may have axonal projections through the hippocampal commissure. This study has utilized a combined immunocytochemical and retrograde transport method as well as 2 anterograde electron-microscopic methods to determine the existence of this projection in rats. Combined tracer and immunofluorescence studies showed several double-labeled GABAergic neurons in the hilus contralateral to the injection site. The electron-microscopic studies revealed both degenerating and HRP-labeled commissural axons that formed symmetric synapses, the type shown to be formed by GABAergic terminals in the hippocampus. These data demonstrate a GABAergic component within the hippocampal commissural pathway and add further evidence that cortical GABAergic terminals are not derived exclusively from intrinsic neurons. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt0247n7tw; https://escholarship.org/uc/item/0247n7tw; https://escholarship.org/content/qt0247n7tw/qt0247n7tw.pdf |
| DOI: |
10.1523/jneurosci.06-12-03492.1986 |
| Availability: |
https://escholarship.org/uc/item/0247n7tw; https://escholarship.org/content/qt0247n7tw/qt0247n7tw.pdf; https://doi.org/10.1523/jneurosci.06-12-03492.1986 |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.6BC28B80 |
| Database: |
BASE |