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Ultrafast-acting insulin: pharmacological properties and their impact on clinical aspects ; Сверхбыстрые инсулины: фармакологические свойства и их влияние на клинические аспекты

Title: Ultrafast-acting insulin: pharmacological properties and their impact on clinical aspects ; Сверхбыстрые инсулины: фармакологические свойства и их влияние на клинические аспекты
Authors: L. A. Suplotova; A. Sh. Tilkiyan; Л. А. Суплотова; А. Ш. Тилкиян
Source: Meditsinskiy sovet = Medical Council; № 13 (2024); 146-154 ; Медицинский Совет; № 13 (2024); 146-154 ; 2658-5790 ; 2079-701X
Publisher Information: REMEDIUM GROUP Ltd.
Publication Year: 2024
Collection: Medical Council (E-Journal) / Медицинский Совет
Subject Terms: помпа; postprandial hyperglycemia; safety; efficacy; diabetes mellitus; biosimilar; pump; постпрандиальная гипергликемия; безопасность; эффективность; сахарный диабет; биосимиляр
Description: The goal of modern insulin therapy used in the treatment of diabetes mellitus is to mimic physiologic insulin secretion by pancreatic beta cells. The new ultrafast-acting insulin analog aspart (UFAiAsp) demonstrates a faster onset and shorter duration of action compared to the ultra-short-acting insulin analog aspart (USAIasp), which substantiates the possibility of insulin administration immediately before meals, which helps to improve glycemic control by regulating postprandial glucose levels, improving patients' quality of life. We conducted a literature search for the period from 2012 to 2023 in the electronic databases PubMed, Elibrary.ru, and Cophrane library of scientific information on the efficacy and safety of ultrafast-acting insulin aspart in comparison with USAIasp. With the use of UFAiAsp, a reduced risk of late postprandial hypoglycemia due to increased absorption rate and earlier termination of the sugar-lowering effect was observed. The problem of using ultrafast-acting insulin aspart in our country, which is solved by the admission of biosimilar drugs (biosimilars) to the market, is considered. It was shown that the domestically produced biosimilar UFAiAsp (RinFast® Nick) registered in the Russian Federation is recognized as interchangeable with the original UFAiAsp (Fiasp®) in terms of bio- and therapeutic equivalence, immune safety, good tolerability, and also meets the specification norms when used for continuous subcutaneous infusion in terms of physicochemical parameters. Dosing accuracy and absence of occlusions in the systems over 72 hours with the new biosimilar in pumps have been proven. Consequently, UFAiAsp can be recommended for all patients, including children, who require the prandial component of insulin therapy. ; Целью современной инсулинотерапии, применяемой при лечении сахарного диабета, является имитация физиологической секреции инсулина бета-клетками поджелудочной железой. Новый сверхбыстрый аналог инсулина аспарт (СБДиАсп) демонстрирует более быстрое начало и более ...
Document Type: article in journal/newspaper
File Description: application/pdf
Language: Russian
Relation: https://www.med-sovet.pro/jour/article/view/8510/7481; Хаар Х, Хайзе Т. Сверхбыстродействующий инсулин аспарт: фармакокинетические и фармакодинамические свойства и их влияние на клинические эффекты. Сахарный диабет. 2020;23(2):140-160. https://doi.org/10.14341/DM12357.; Демидова ТЮ, Измайлова МЯ. Сверхбыстродействующий инсулин аспарт - от портрета инсулина к портретам пациентов. Медицинский совет. 2021;(7):8-16. https://doi.org/10.21518/2079-701X-2021-7-8-16.; Heise T, Stender-Petersen K, Hovelmann U, Jacobsen JB, Nosek L, Zijlstra E, Haahr H. Pharmacokinetic and Pharmacodynamic Properties of Faster-Acting Insulin Aspart versus Insulin Aspart Across a Clinically Relevant Dose Range in Subjects with Type 1 Diabetes Mellitus. Clin Pharmacokinet. 2017;56(6):649-660. https://doi.org/10.1007/s40262-016-0473-5.; Саверская ЕН, Кокшарова ЕО, Носков СМ, Заикин ПГ, Банко ВВ, Арефьева АН. Результаты оценки биоподобия препаратов инсулина аспарт отечественного и зарубежного производства с использованием метода гиперинсулинемического эугликемического клэмпа и исследования применения нового сверхбыстродействующего отечественного биосимиляра в помпах. Медицинский совет. 2024;18(1):43-50. https://doi.org/10.21518/ms2024-023.; Булгакова СВ, Саверская ЕН, Шаронова ЛА, Долгих ЮА, Косарева ОВ. Биосимиляр аналога инсулина гларгин: доказанная безопасность, эффективность, взаимозаменяемость. Медицинский совет. 2022;16(23):207-214. https://doi.org/10.21518/2079-701X-2022-16-23-207-214.; Evans M, Wilkinson M, Giannpolou A. Fast-Acting Insulin Aspart: The Rationale for a New Mealtime Insulin. Diabetes Ther. 2019;1O(5):1793-180O. https://doi.org/10.1007/s13300-019-00685-0.; Evans M, Ceriello A, Danne T, De Block C, DeVries JH, Lind M et al. Use of fast-acting insulin aspart in insulin pump therapy in clinical practice. Diabetes Obes Metab. 2019;21(9):2039-2047. https://doi.org/10.1111/dom.13798.; McNeal CJ, Meininger CJ, Reddy D, Wilborn CD, Wu G. Safety and effectiveness of arginine in adults. J Nutr. 2016;146(12):2587S-2593S. https://doi.org/10.3945/jn.116.234740.; Kildegaard J, Buckley ST, Nielsen RH, Povlsen GK, Seested T, Ribel U et al. Elucidating the mechanism of absorption of fast-acting insulin aspart: the role of niacinamide. Pharm Res. 2019;36(3):49. https://doi.org/10.1007/s11095-019-2578-7.; Billion L, Charleer S, Registrar VLJ, Registrar SMJ, Registrar VKJ, De Block N et al. Glucose control using fast-acting insulin aspart in a real-world setting: A 1-year, two-centre study in people with type 1 diabetes using continuous glucose monitoring. Diabetes Obes Metab. 2021;23(12):2716-2727. https://doi.org/10.1111/dom.14527.; Dutta D, Mohindra R, Mahajan K, Sharma M. Performance of Fast-Acting Aspart Insulin as Compared to Aspart Insulin in Insulin Pump for Managing Type 1 Diabetes Mellitus: A Meta-Analysis. Diabetes Metab J. 2023;47(1):72-81. https://doi.org/10.4093/dmj.2022.0035.; Buse JB, Carlson AL, Komatsu M, Mosenzon O, Rose L, Liang B et al. Fast-acting insulin aspart versus insulin aspart in the setting of insulin degludec-treated type 1 diabetes: Efficacy and safety from a randomized double-blind trial. Diabetes Obes Metab. 2018;20(12):2885-2893. https://doi.org/10.1111/dom.13545.; Lind M, Catrina SB, Ekberg NR, Gerward S, Halasa T, Hellman J et al. Fast-Acting Insulin Aspart in Patients with Type 1 Diabetes in Real-World Clinical Practice: A Noninterventional, Retrospective Chart and Database Study. Diabetes Ther. 2023;14(9):1563-1575. https://doi.org/10.1007/s13300-023-01444-y.; Каронова ТЛ, Майоров АЮ. Изучение эквивалентности и сопоставимой иммуногенности биосимиляра инсулина аспарт в сравнении с зарегистрированным аналогом. Медицинский совет. 2022;16(10):75-82. https://doi.org/10.21518/2079-701X-2022-16-10-75-82.; Дедов ИИ, Шестакова МВ, Петеркова ВА, Майоров АЮ, Галстян ГР, Викулова ОК. Проект рекомендаций Российской ассоциации эндокринологов по применению биосимиляров инсулина. Сахарный диабет. 2021;24(1):76-79. Режим доступа: https://www.dia-endojournals.ru/jour/article/view/12739.; Shiramoto M, Nishida T, Hansen AK, Haahr H. Fast-acting insulin aspart in Japanese patients with type 1 diabetes: Faster onset, higher early exposure and greater early glucose-lowering effect relative to insulin aspart. J Diabetes Investig. 2018;9(2):303-310. https://doi.org/10.1111/jdi.12697.; Haahr H, Pieber TR, Mathieu C, Gondolf T, Shiramoto M, Erichsen L, Heise T. Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus. Clin Pharmacokinet. 2019;58(5):639-649. https://doi.org/10.1007/s40262-018-0718-6.; Pieber TR, Svehlikova E, Brunner M, Halberg IB, Due Thomsen KM, Haahr H. Fast-acting insulin aspart in people with type 2 diabetes: Earlier onset and greater initial exposure and glucose-lowering effect compared with insulin aspart. Diabetes Obes Metab. 2019;21(9):2068-2075. https://doi.org/10.1111/dom.13767.; Hovelmann U, Heise T, Nosek L, Sassenfeld B, Thomsen KMD, Haahr H. Pharmacokinetic Properties of Fast-Acting Insulin Aspart Administered in Different Subcutaneous Injection Regions. Clin Drug Investig. 2017;37(5):503-509. https://doi.org/10.1007/s40261-017-0499-y.; Koufakis T, Dhatariya KK, Kotsa K. Potential Role of Ultrafast-acting Insulin Analogues in the Treatment of Diabetic Ketoacidosis. J Clin Endocrinol Metab. 2022;107(10):e4259-e4260. https://doi.org/10.1210/clinem/dgac301.; Mathieu C, Bode BW, Franek E, Philis-Tsimikas A, Rose L, Graungaard T et al. Efficacy and safety of fast-acting insulin aspart in comparison with insulin aspart in type 1 diabetes (onset 1): A 52-week, randomized, treatto-target, phase III trial. Diabetes Obes Metab. 2018;20(5):1148-1155. https://doi.org/10.1111/dom.13205.; Russell-Jones D, Bode BW, de Block C, Franek E, Heller SR, Mathieu C et al. Fast-acting insulin aspart improves glycemic control in basal-bolus treatment for type 1 diabetes: Results of a 26-week multicenter, active-controlled, treat-to-target, randomized, parallelgroup trial (onset 1). Diabetes Care. 2017;40(7):943-950. https://doi.org/10.2337/dc16-1771.; Danne T, Schweitzer MA, Keuthage W, Kipper S, Kretzschmar Y, Simon J et al. Impact of Fast-Acting Insulin Aspart on Glycemic Control in Patients with Type 1 Diabetes Using Intermittent-Scanning Continuous Glucose Monitoring Within a Real-WorldSetting: The GoBolus Study. Diabetes Technol Ther. 2021;23(3):203-212. https://doi.org/10.1089/dia.2020.0360.; Bowering K, Case C, Harvey J, Reeves M, Sampson M, Strzinek R et al. Faster Aspart Versus Insulin Aspart as Part of a Basal-Bolus Regimen in Inadequately Controlled Type 2 Diabetes: The onset 2 Trial. Diabetes Care. 2017;40(7):951-957. https://doi.org/10.2337/dc16-1770.; Lane WS, Favaro E, Rathor N, Jang HC, Kjærsgaard MIS, Oviedo A et al. A Randomized Trial Evaluating the Efficacy and Safety of Fast-Acting Insulin Aspart Compared With Insulin Aspart, Both in Combination With Insulin Degludec With or Without Metformin, in Adults With Type 2 Diabetes (ONSET 9). Diabetes Care. 2020;43(8):1710-1716. https://doi.org/10.2337/dc19-2232.; Rodbard HW, Tripathy D, Vidrio Velazquez M, Demissie M, Tamer SC, Piletic M. Adding fast-acting insulin aspart to basal insulin significantly improved glycaemic control in patients with type 2 diabetes: A randomized, 18-week, open-label, phase 3 trial (onset 3). Diabetes Obes Metab. 2017;19(10):1389-1396. https://doi.org/10.1111/dom.12955.; Svehlikova E, Mursic I, Augustin T, Magnes C, Gerring D, Jezek J et al. Pharmacokinetics and Pharmacodynamics of Three Different Formulations of Insulin Aspart: A Randomized, Double-Blind, Crossover Study in Men With Type 1 Diabetes. Diabetes Care. 2021;44(2):448-455. https://doi.org/10.2337/dc20-1017.; Cengiz E, Bode B, Van Name M, Tamborlane WV. Moving toward the ideal insulin for insulin pumps. Expert Rev Med Devices. 2016;13(1):57-69. https://doi.org/10.1586/17434440.2016.1109442.; Fatourechi MM, Kudva YC, Murad MH, Elamin MB, Tabini CC, Montori VM. Clinical review: Hypoglycemia with intensive insulin therapy: a systematic review and meta-analyses of randomized trials of continuous subcutaneous insulin infusion versus multiple daily injections. J Clin Endocrinol Metab. 2009;94(3):729-740. https://doi.org/10.1210/jc.2008-1415.; Wei J, Wang Y. Effectiveness of Faster Aspart versus Insulin Aspart in Children with Type 1 Diabetes: A Meta-Analysis. Iran J Public Health. 2024;53(1):23-34. https://doi.org/10.18502/ijph.v53i1.14680.; Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, DeVries JH et al. A ran-domized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabetes (onset 5). Diabetes Obes Metab. 2019;21(4):961-967. https://doi.org/10.1111/dom.13610.; Basu A, Pieber TR, Hansen AK, Sach-Friedl S, Erichsen L, Basu R, Haahr H. Greater early postprandial suppression of endogenous glucose production and higher initial glucose disappearance is achieved with fast-acting insulin aspart compared with insulin aspart. Diabetes Obes Metab. 2018;20(7):1615-1622. https://doi.org/10.1111/dom.13270.; Ozer K, Cooper AM, Ahn LP, Waggonner CR, Blevins TC. Fast Acting Insulin Aspart Compared with Insulin Aspart in the Medtronic 670G Hybrid Closed Loop System in Type 1 Diabetes: An Open Label Crossover Study. Diabetes Technol Ther. 2021;23(4):286-292. https://doi.org/10.1089/dia.2020.0500.; Zijlstra E, Demissie M, Graungaard T, Heise T, Nosek L, Bode B. Investigation of Pump Compatibility of Fast-Acting Insulin Aspart in Subjects With Type 1 Diabetes. J Diabetes Sci Technol. 2018;12(1):145-151. https://doi.org/10.1177/1932296817730375.; Beck RW, Russell SJ, Damiano ER, El-Khatib FH, Ruedy KJ, Balliro C, Li Z, Calhoun P. A Multicenter Randomized Trial Evaluating Fast-Acting Insulin Aspart in the Bionic Pancreas in Adults with Type 1 Diabetes. Diabetes Technol Ther. 2022;24(10):681-696. https://doi.org/10.1089/dia.2022.0167.; Yadav A, Kumar R, Dayal D, Yadav J, Pattanaik S, Patil A. Effect of Postmeal Fast-Acting Insulin Aspart Injection on the Frequency of Hypoglycemia among Pre-School Children with Type 1 Diabetes: An Open-Label, Cross-Over, Randomized Control Trial. Indian J Pediatr. 2023. https://doi.org/10.1007/s12098-023-04844-x.; Senior P, Hramiak I. Fast-Acting Insulin Aspart and the Need for New Mealtime Insulin Analogues in Adults With Type 1 and Type 2 Diabetes: A Canadian Perspective. Can J Diabetes. 2019;43(7):515-523. https://doi.org/10.1016/j.jcjd.2019.01.004.; Paquot N, Scheen AJ. Faster aspart insulin (FIASP®). Rev Med Liege. 2018;73(4):211-215. Available at: https://pubmed.ncbi.nlm.nih.gov/29676875/.; Fath M, Danne T, Biester T, Erichsen L, Kordonouri O, Haahr H. Faster-acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus. Pediatr Diabetes. 2017;18(8):903-910. https://doi.org/10.1111/pedi.12506.; Wong EY, Kroon L. Ultra-Rapid-Acting Insulins: How Fast Is Really Needed? Clin Diabetes. 2021;39(4):415-423. https://doi.org/10.2337/cd20-0119.
DOI: 10.21518/ms2024-262
Availability: https://www.med-sovet.pro/jour/article/view/8510; https://doi.org/10.21518/ms2024-262
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Accession Number: edsbas.6BD66FEA
Database: BASE