| Title: |
Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders |
| Authors: |
Sota J.; Guerriero S.; Lopalco G.; Tufan A.; Ragab G.; AlMaglouth I.; Govoni M.; Sfikakis P. P.; Frassi M.; Vitale A.; Kardas R. C.; Triaggianese P.; Chimenti M. S.; Aboabat A. A.; Piga M.; Monti S.; Sebastiani G. D.; Yildirim D.; Conforti A.; Gentileschi S.; Dammacco R.; Hinojosa-Azaola A.; Kawakami-Campos P. A.; Ruffilli F.; Torres-Ruiz J.; Thabet M.; Atig A.; Ruscitti P.; Cataldi G.; Viapiana O.; Hatemi G.; Karakoc A.; Costi S.; Iagnocco A.; Crisafulli F.; Fragoulis G.; Del Giudice E.; Hegazy M. T.; Paroli M. P.; Sahin A.; Morrone M.; Iannone F.; Opris-Belinski D.; Asfina K. N.; Barone P.; Gaggiano C.; Kucuk H.; Gicchino M. F.; Carubbi F.; Caggiano V.; Laskari K.; Tharwat S.; Direskeneli H.; Alibaz-Oner F.; Sevik G.; Maier A.; Laymouna A. H.; Emmi G.; Akkoc N.; Tarsia M.; Sbalchiero J.; Conti G.; Spinella R.; La Torre F.; Tombetti E.; Amin R. H.; Mauro A.; Karamanakos A.; Carreno E.; Fonollosa A.; Cattalini M.; Breda L.; de-la-Torre A.; Wiesik-Szewczyk E.; Cifuentes-Gonzalez C.; Ozen S.; Mazzei M. A.; Tosi G. M.; Frediani B.; Balistreri A.; Batu E. D.; Gupta V.; Cantarini L.; Fabiani C. |
| Contributors: |
J. Sota; S. Guerriero; G. Lopalco; A. Tufan; G. Ragab; I. Almaglouth; M. Govoni; P.P. Sfikaki; M. Frassi; A. Vitale; R.C. Karda; P. Triaggianese; M.S. Chimenti; A.A. Aboabat; M. Piga; S. Monti; G.D. Sebastiani; D. Yildirim; A. Conforti; S. Gentileschi; R. Dammacco; A. Hinojosa-Azaola; P.A. Kawakami-Campo; F. Ruffilli; J. Torres-Ruiz; M. Thabet; A. Atig; P. Ruscitti; G. Cataldi; O. Viapiana; G. Hatemi; A. Karakoc; S. Costi; A. Iagnocco; F. Crisafulli; G. Fragouli; E. Del Giudice; M.T. Hegazy; M.P. Paroli; A. Sahin; M. Morrone; F. Iannone; D. Opris-Belinski; K.N. Asfina; P. Barone; C. Gaggiano; H. Kucuk; M.F. Gicchino; F. Carubbi; V. Caggiano; K. Laskari; S. Tharwat; H. Direskeneli; F. Alibaz-Oner; G. Sevik; A. Maier; A.H. Laymouna; G. Emmi; N. Akkoc; M. Tarsia; J. Sbalchiero; G. Conti; R. Spinella; F. La Torre; E. Tombetti; R.H. Amin; A. Mauro; A. Karamanako; E. Carreno; A. Fonollosa; M. Cattalini; L. Breda; A. de-la-Torre; E. Wiesik-Szewczyk; C. Cifuentes-Gonzalez; S. Ozen; M.A. Mazzei; G.M. Tosi; B. Frediani; A. Balistreri; E.D. Batu; V. Gupta; L. Cantarini; C. Fabiani |
| Publisher Information: |
Taylor and Francis Ltd. |
| Publication Year: |
2025 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
AIDA network uveitis registry; Behçet’s disease; HLA-B51; non-infectious uveiti; retinal vasculitis; Settore MEDS-09/C - Reumatologia; Settore MEDS-05/A - Medicina interna |
| Description: |
Purpose: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet’s disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown. Methods: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time. Results: Records of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99). Conclusions: Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/38759215; info:eu-repo/semantics/altIdentifier/wos/WOS:001225323400001; volume:33; issue:1; firstpage:48; lastpage:55; numberofpages:8; journal:OCULAR IMMUNOLOGY AND INFLAMMATION; https://hdl.handle.net/2434/1125357 |
| DOI: |
10.1080/09273948.2024.2346815 |
| Availability: |
https://hdl.handle.net/2434/1125357; https://doi.org/10.1080/09273948.2024.2346815 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.6C1DF46F |
| Database: |
BASE |