| Title: |
Low Free Testosterone and Prostate Cancer Risk: A Collaborative Analysis of 20 Prospective Studies |
| Authors: |
Watts, EL; Appleby, PN; Perez-Cornago, A; Bueno-de-Mesquita, HB; Chan, JM; Chen, C; Cohn, BA; Cook, MB; Flicker, L; Freedman, ND; Giles, GG; Giovannucci, E; Gislefoss, RE; Hankey, GJ; Kaaks, R; Knekt, P; Kolonel, LN; Kubo, T; Le Marchand, L; Luben, RN; Luostarinen, T; Männistö, S; Metter, EJ; Mikami, K; Milne, RL; Ozasa, K; Platz, EA; Quirós, JR; Rissanen, H; Sawada, N; Stampfer, M; Stanczyk, FZ; Stattin, P; Tamakoshi, A; Tangen, CM; Thompson, IM; Tsilidis, KK; Tsugane, S; Ursin, G; Vatten, L; Weiss, NS; Yeap, BB; Allen, NE; Key, TJ; Travis, RC |
| Publisher Information: |
ELSEVIER SCIENCE BV |
| Publication Year: |
2018 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
BACKGROUND: Experimental and clinical evidence implicates testosterone in the aetiology of prostate cancer. Variation across the normal range of circulating free testosterone concentrations may not lead to changes in prostate biology, unless circulating concentrations are low. This may also apply to prostate cancer risk, but this has not been investigated in an epidemiological setting. OBJECTIVE: To examine whether men with low concentrations of circulating free testosterone have a reduced risk of prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: Analysis of individual participant data from 20 prospective studies including 6933 prostate cancer cases, diagnosed on average 6.8 yr after blood collection, and 12 088 controls in the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Odds ratios (ORs) of incident overall prostate cancer and subtypes by stage and grade, using conditional logistic regression, based on study-specific tenths of calculated free testosterone concentration. RESULTS AND LIMITATIONS: Men in the lowest tenth of free testosterone concentration had a lower risk of overall prostate cancer (OR=0.77, 95% confidence interval [CI] 0.69-0.86; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0302-2838 |
| Relation: |
https://hdl.handle.net/11343/270966 |
| Availability: |
https://hdl.handle.net/11343/270966 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.6CA8E265 |
| Database: |
BASE |