Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group
| Title: | Subcortical brain alterations in major depressive disorder: findings from the ENIGMA Major Depressive Disorder working group |
|---|---|
| Authors: | Schmaal, L; Veltman, DJ; van Erp, TGM; Samann, PG; Frodl, T; Jahanshad, N; Loehrer, Elizabeth; Tiemeier, Henning; Hofman, Bert; Niessen, Wiro; Vernooij, Meike; Ikram, Arfan; Wittfeld, K; Grabe, HJ; Block, A; Hegenscheid, K; Volzke, H; Hoehn, D; Czisch, M; Lagopoulos, J; Hatton, SN; Hickie, IB; Goya-Maldonado, R; Kramer, B; Gruber, O; Couvy-Duchesne, B; Renteria, ME; Strike, LT; Mills, NT; de Zubicaray, GI; McMahon, KL; Medland, SE; Martin, NG; Gillespie, NA; Wright, MJ; Hall, GB; MacQueen, GM; Frey, EM; Carballedo, A; van Velzen, LS; van Tol, MJ; van der Wee, NJ; Veer, IM; Walter, H; Schnell, K; Schramm, E; Normann, C; Schoepf, D; Konrad, C; Zurowski, B; Nickson, T; McIntosh, AM; Papmeyer, M; Whalley, HC; Sussmann, JE; Godlewska, BR; Cowen, PJ; Fischer, FH; Rose, M; Penninx, BWJH; Thompson, PM; Hibar, DP |
| Source: | Schmaal, L, Veltman, DJ, van Erp, TGM, Samann, PG, Frodl, T, Jahanshad, N, Loehrer, E, Tiemeier, H, Hofman, B, Niessen, W, Vernooij, M, Ikram, A, Wittfeld, K, Grabe, HJ, Block, A, Hegenscheid, K, Volzke, H, Hoehn, D, Czisch, M, Lagopoulos, J, Hatton, SN, Hickie, IB, Goya-Maldonado, R, Kramer, B, Gruber, O, Couvy-Duchesne, B, Renteria, ME, Strike, LT, Mills, NT, de Zubicaray, GI, McMahon, KL, Medland, SE, Martin, NG, Gillespie, NA, Wright, MJ, Hall, GB, MacQueen, GM, Frey, EM, Carballedo, A, van Velzen, LS, van Tol, MJ, van der Wee, NJ, Veer, IM, Walter, H, Schnell, K, Schramm, E, Normann, .... |
| Publication Year: | 2016 |
| Subject Terms: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES016401; name=EMC NIHES-01-64-01; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCNIHES045501; name=EMC NIHES-04-55-01; /dk/atira/pure/keywords/researchprograms/AFL001000/EMCONWAR015802; name=EMC ONWAR-01-58-02 |
| Description: | The pattern of structural brain alterations associated with major depressive disorder (MDD) remains unresolved. This is in part due to small sample sizes of neuroimaging studies resulting in limited statistical power, disease heterogeneity and the complex interactions between clinical characteristics and brain morphology. To address this, we meta-analyzed three-dimensional brain magnetic resonance imaging data from 1728 MDD patients and 7199 controls from 15 research samples worldwide, to identify subcortical brain volumes that robustly discriminate MDD patients from healthy controls. Relative to controls, patients had significantly lower hippocampal volumes (Cohen's d=-0.14, % difference=-1.24). This effect was driven by patients with recurrent MDD (Cohen's d=-0.17, % difference=-1.44), and we detected no differences between first episode patients and controls. Age of onset |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| ISSN: | 1359-4184; 1476-5578 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26122586; info:eu-repo/semantics/altIdentifier/pissn/1359-4184; info:eu-repo/semantics/altIdentifier/eissn/1476-5578 |
| DOI: | 10.1038/mp.2015.69 |
| Availability: | https://pure.eur.nl/en/publications/83c8527e-bf16-4124-8275-2f212e4f0f0b; https://doi.org/10.1038/mp.2015.69; https://pure.eur.nl/ws/files/47674795/REPUB_86136_OA.pdf; https://hdl.handle.net/1765/86136 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.6CEB6EDE |
| Database: | BASE |