| Title: |
A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice |
| Authors: |
McIntyre, RE; Nicod, J; Daniela Robles-Espinoza, C; Maciejowski, J; Cai, N; Hill, J; Verstraten, R; Iyer, V; Rust, AG; Balmus, G; Mott, R; Flint, J; Adams, DJ |
| Source: |
G3 , 6 (8) pp. 2343-2354. (2016) |
| Publisher Information: |
GENETICS SOCIETY AMERICA |
| Publication Year: |
2016 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Science & Technology; Life Sciences & Biomedicine; Genetics & Heredity; Micronuclei; genomic instability; genome-wide association study (GWAS); Outbred mice; genetic mapping; AICARDI-GOUTIERES-SYNDROME; VARIANT ANNOTATION; PERIPHERAL-BLOOD; SEX DISPARITIES; CANCER; GENES; MOUSE; GENERATION; PROTEIN; CHROMOTHRIPSIS |
| Description: |
In mammals the regulation of genomic instability plays a key role in tumor suppression and also controls genome plasticity, which is important for recombination during the processes of immunity and meiosis. Most studies to identify regulators of genomic instability have been performed in cells in culture or in systems that report on gross rearrangements of the genome, yet subtle differences in the level of genomic instability can contribute to whole organism phenotypes such as tumor predisposition. Here we performed a genome-wide association study in a population of 1379 outbred Crl:CFW(SW)-US_P08 mice to dissect the genetic landscape of micronucleus formation, a biomarker of chromosomal breaks, whole chromosome loss, and extranuclear DNA. Variation in micronucleus levels is a complex trait with a genome-wide heritability of 53.1%. We identify seven loci influencing micronucleus formation (false discovery rate |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/1503765/1/2343.full.pdf; https://discovery.ucl.ac.uk/id/eprint/1503765/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/1503765/1/2343.full.pdf; https://discovery.ucl.ac.uk/id/eprint/1503765/ |
| Rights: |
open |
| Accession Number: |
edsbas.6D23AEBF |
| Database: |
BASE |