RANDOMIZED CONTROLLED TRIAL OF STREPTOKINASE, ASPIRIN, AND COMBINATION OF BOTH IN TREATMENT OF ACUTE ISCHEMIC STROKE
| Title: | RANDOMIZED CONTROLLED TRIAL OF STREPTOKINASE, ASPIRIN, AND COMBINATION OF BOTH IN TREATMENT OF ACUTE ISCHEMIC STROKE |
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| Authors: | CANDELISE L; ARITZU E; CICCONE A; RICCI S; WARDLAW J; TOGNONI G; RONCAGLIONI MC; NEGRI E; COLOMBO F; BOCCARDI E; DEGRANDI C; SCIALFA G; ARGENTINO C; BERTELE V; MAGGIONI AP; PERRONE P; BARNETT HJM; BOGOUSSLAVSKY J; DELFAVERO A; LOI U; PETO R; WARLOW C; CANZI S; COMPARETTI S; CLERICI F; PALUMBO A; SGARONI G; POLONARA S; REGINELLI R; CERAVOLO MG; PROVINCIALI L; DELGOBBO M; SCARPINO O; BOTTACCHI E; DALESSANDRO G; DIGIOVANNI M; BLANC S; ROVEYAZ L; RALLI L; VANNI D; REFI C; FEDERICO F; CONTE C; INCHINGOLO V; INSABATO R; SALSA F; LORIZIO A; ROTTOLI MR; BRUNI L; DEFANTI CA; FERA L; CAMERLINGO M; CASTO L; CENSORI B; MAMOLI A; PORAZZI D; GRAMPA G; LASPINA I; GIGLIA L; AVENIA V; GUELI S; LOLLI V; MIELE V; SANTANGELO M; COPPOLA G; TRIANNI G; MARRA M; GRECO E; TONTI D; PRETOLANI E; STELLIO M; ARNABOLDI M; CIOLA R; DANIELI G; REZZONICO M; GUIDOTTI M; PELLEGRINI G; RAUDINO F; DELFAVERO C; FRATTINI T; RICCARDI T; LEVIMINZI C; LOCATELLI F; PASSERI F; LOMBARDO G; COCCO F; PRATESI M; SANTINI S; CARDOPATRI F; TAFANI O; LANDINI GC; PIERAGNOLI E; BELLESI R; BAGNOLI L; GHETTI A; MARRAZZA OB; MENEGAZZO P; SPOLVERI S; CAPPELLETTI C; CANDELIERE G; COSTANTINO G; DACUNO F; LOMUZIO T; RIZZITELLI FP; BOVIO G; GRILLI GP; ZOCCHI M; MAZZANTI I; PISAPIA G; NUZZI R; RUSSO G; LAMA G; BALDASSARRI G; BETTINI R; CANI E; CERIOLI E; DEGIORGI M; GARAGNANI A; PASQUALI S; CHIOMA V; FINI C; MARZARA G; BALOTTA A; BERTUZZI D; MASINA M; MATACENA C; MICHELINI M; PIRAZZOLI G; SACCHET C; MAROTTA P; CALVI L; SCACCABAROZZI C; MENOZZI C; SASANELLI F; BASCELLI C; PONTRELLI V; SCHIERONI F; BELVEDERE D; DECAPITANI E; DICOSTANZO M; RASCAROLI M; CITTERIO O; MILANI R; CAPIALBI R; ARENA G; MUSOLINO R; DIPERRI R; BONAVENTI C; FINZI F; MESSINA A; ROMANAZZI V; STERZI R; BOTTINI G; SANTILLI I; BRUCATO A; DEJULI E; PALMIERI G; RAGAINI S; THIELLA G; ALLI C; CAROSELLA L; RIZZATO G; BIANCHI M; MOTTO C; PINARDI G; SCARLATO G; BETTINELLI A; PORRO F; RANDAZZO A; MARINI U; LATTUADA P; PIETRA A; FRANCESCHI M; VOLOUTE MA; MALFERRARI G; BONDI M; GARUTI W; MELINI L; COLOMBO A; ALBORINI G; PANZETTI P; SCARPA M; SORGATO P; CRISI G; BONASERA N; BASSO F; NATALI E; MONACO P; GASPARRO AM; TRIOLO F; LECHI A; COLONNA F; DASCOLA I; GIORGI C; SCODITTI U; BASSI P; MENOZZI R; PIAZZA P; DEGLIANTONI G; DESIMONI M; GIANNINI A; MICILI G; BOSONE D; CAVALLINI A; MARTELLI A; BARZIZZA F; POLI M; BIAGINI S; CAPOCCHI G; CELANI MG; PICCHIARELLI A; RIGHETTI E; ZAMPOLINI M; CAPUTO N; BARTOLINI S; SANTONI M; SITA D; TAGLIOLI M; VOLPI G; ROSSI F; ALOY F; CASTELLANO AE; MINOTTA F; GATTA A; VINATTIERI A; CANTINI A; REBUCCI GG; BISSI G; DEBLASI F; PASCARELLI E; TURIAMO F; GUIDETTI D; BARATTI M; FERRARINI G; GHIDONI E; GRECO G; MARCELLO N; MOTTI L; SOLIME F; TERENZIANI S; ZUCCO R; TROISO A; VENEZIANI M; IORI I; CURATOLA L; BOLLETTINI G; CARBONI T; GOBBATO R; INFRICCIOLO P; SABATINI D; SFRAPPINI M; FANCELLU A; CASU G; DELEDDA MG; SPANU MA; PIRISI A; MARRAS FA; ROSATI G; BRAMBILLA A; ERLI GC; FELICE B; GRANDI R; MIRABILE D; ZADRA M; CAVESTRI R; GORI D; LONGHINI E; MIELE N; DIVIZIA G; GRASSELLI S; PEZZELLA F; ZUCCARI F; SALLUSTO L; LINCESSO F; SCARPATI C; IANNONE G; BARTOCCI A; COSTANTINI F; DESANTIS L; LANCIA G; MOSCHINI E; PACI A; SENSIDONI A; TRENTA A; BARTOLINI N; OTTAVIANO P; BISCOTTINI B; ALUNNI G; BARTOLINI I; BELLADONNA D; BOCCALI A; CRUCIANI M; IBBA R; LUCCIOLI R; MARCECA A; PACINI M; PALLONE M; GIRARDI P; ORRICO D; LANZA E; BALLINI A; GRANDI FC; MUSCO G; STEIDL L; SANTORO G; VEMCO A; DUDINE P; MILONE FF; MUNARI L; PERRETI A; PORTA M; LONGONI C; FERANI R; WATT M; SANDERCOCK P; FENNETRY A; BANNISTER P; CLARKE CE; BAMFORD J; VENABLES G; CORREIA M |
| Contributors: | CANDELISE L; ARITZU E; CICCONE A; RICCI S; WARDLAW J; TOGNONI G; RONCAGLIONI MC; NEGRI E; COLOMBO F; BOCCARDI E; DEGRANDI C; SCIALFA G; ARGENTINO C; BERTELE V; MAGGIONI AP; PERRONE P; BARNETT HJM; BOGOUSSLAVSKY J; DELFAVERO A; LOI U; PETO R; WARLOW C; CANZI S; COMPARETTI S; CLERICI F; PALUMBO A; SGARONI G; POLONARA S; REGINELLI R; CERAVOLO MG; PROVINCIALI L; DELGOBBO M; SCARPINO O; BOTTACCHI E; DALESSANDRO G; DIGIOVANNI M; BLANC S; ROVEYAZ L; RALLI L; VANNI D; REFI C; FEDERICO F; CONTE C; INCHINGOLO V; INSABATO R; SALSA F; LORIZIO A; ROTTOLI MR; BRUNI L; DEFANTI CA; FERA L; CAMERLINGO M; CASTO L; CENSORI B; MAMOLI A; PORAZZI D; GRAMPA G; LASPINA I; GIGLIA L; AVENIA V; GUELI S; LOLLI V; MIELE V; SANTANGELO M; COPPOLA G; TRIANNI G; MARRA M; GRECO E; TONTI D; PRETOLANI E; STELLIO M; ARNABOLDI M; CIOLA R; DANIELI G; REZZONICO M; GUIDOTTI M; PELLEGRINI G; RAUDINO F; DELFAVERO C; FRATTINI T; RICCARDI T; LEVIMINZI C; LOCATELLI F; PASSERI F; LOMBARDO G; COCCO F; PRATESI M; SANTINI S; CARDOPATRI F; TAFANI O; LANDINI GC; PIERAGNOLI E; BELLESI R; BAGNOLI L; GHETTI A; MARRAZZA OB; MENEGAZZO P; SPOLVERI S; CAPPELLETTI C; CANDELIERE G |
| Publication Year: | 1995 |
| Collection: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Description: | In ischaemic stroke, thrombolytic drugs speed the recanalisation of intracerebral arteries. The effects of aspirin are not known. A trial was conducted to determine whether, separately or together, streptokinase and aspirin have clinical benefits in acute ischaemic stroke similar to those in acute myocardial infarction. 622 patients with acute ischaemic stroke within 6 hours of symptom onset were randomised with a 2x2 factorial design to (i) a 1-hour intravenous infusion of 1 . 5 MU streptokinase, (ii) 300 mg/day buffered aspirin for 10 days, (iii) both active treatments, or (iv) neither. Early results raised a question whether the trial should be continued. Streptokinase (alone or with aspirin) was associated with an excess of 10-day case fatality (odds ratio 2 . 7; 95% confidence interval 1 . 7-4 . 3; 2p |
| Document Type: | article in journal/newspaper |
| Language: | unknown |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:A1995TJ29100008; volume:346; issue:8989; firstpage:1509; lastpage:1514; numberofpages:6; journal:THE LANCET; http://hdl.handle.net/11585/866752 |
| Availability: | http://hdl.handle.net/11585/866752 |
| Accession Number: | edsbas.6D490751 |
| Database: | BASE |