Evaluation of Six Weekly Oral Fecal Microbiota Transplants in People with HIV
| Title: | Evaluation of Six Weekly Oral Fecal Microbiota Transplants in People with HIV |
|---|---|
| Authors: | Netanya Sandler Utay; Ana N. Monczor; Anoma Somasunderam; Sofia Lupo; Zhi-Dong Jiang; Ashley S. Alexander; Malcolm Finkelman; Karen J. Vigil; Jordan E. Lake; Blake Hanson; Herbert L. DuPont; Roberto C. Arduino |
| Source: | Pathogens and Immunity, Vol 5, Iss 1 (2020) |
| Publisher Information: | Case Western Reserve University |
| Publication Year: | 2020 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | HIV; microbiome; fecal microbiota transplant; inflammation; Pathology; RB1-214; Immunologic diseases. Allergy; RC581-607 |
| Description: | Background: Reduced microbiota diversity (dysbiosis) in people with HIV (PWH) likely contributes to inflammation, a driver of morbidity and mortality. We aimed to evaluate the safety and tolerability of 6 weekly oral fecal microbiota transplants (FMT) administered to reverse this dysbiosis. Methods: Six PWH on suppressive antiretroviral therapy (ART) received 6 weekly doses of lyophilized fecal microbiota product from healthy donors. Shotgun sequencing on stool before, after last FMT, and 20 weeks thereafter was performed. Inflammation and gut permeability biomarkers were measured. Results: Median age at week 0 was 39 years, CD4+ T cell count 496 cells/mm3, HIV RNA levels |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://www.paijournal.com/index.php/paijournal/article/view/388; https://doaj.org/toc/2469-2964; https://doaj.org/article/a0ca9d53b37f48ea9d6026b41fee1f5d |
| DOI: | 10.20411/pai.v5i1.388 |
| Availability: | https://doi.org/10.20411/pai.v5i1.388; https://doaj.org/article/a0ca9d53b37f48ea9d6026b41fee1f5d |
| Accession Number: | edsbas.6D5041C1 |
| Database: | BASE |