| Title: |
Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report |
| Authors: |
Blechter, Batel; Hsiung, Chao Agnes; Wang, Xiaoyu; Zhang, Haoyu; Seow, Wei Jie; Shi, Jianxin; Chatterjee, Nilanjan; Kim, Hee Nam; Wong, Maria Pik; Hong, Yun Chul; Wong, Jason Y.Y.; Dai, Juncheng; Hosgood, H. Dean; Wang, Zhaoming; Chang, I. Shou; Choi, Jiyeon; Wang, Jiucun; Song, Minsun; Hu, Wei; Zheng, Wei; Kim, Jin Hee; Zhou, Baosen; Albanes, Demetrius; Shin, Min Ho; Chung, Lap Ping; An, She Juan; Zheng, Hong; Yatabe, Yasushi; Zhang, Xu Chao; Kim, Young Tae; Shu, Xiao Ou; Kim, Young Chul; Vermeulen, Roel C.H.; Bassig, Bryan A.; Chang, Jiang; Man Ho, James Chung; Ji, Bu Tian; Kubo, Michiaki; Daigo, Yataro; Momozawa, Yukihide; Kamatani, Yoichiro; Honda, Takayuki; Kunitoh, Hideo; Watanabe, Shun ichi; Miyagi, Yohei; Nakayama, Haruhiko; Matsumoto, Shingo; Tsuboi, Masahiro; Goto, Koichi; Yin, Zhihua; Takahashi, Atsushi; Goto, Akiteru; Minamiya, Yoshihiro; Shimizu, Kimihiro; Tanaka, Kazumi; Wu, Tangchun; Wei, Fusheng; Su, Jian; Kim, Yeul Hong; Oh, In Jae; Fun Lee, Victor Ho; Su, Wu Chou; Chen, Yuh Min; Chang, Gee Chen; Chen, Kuan Yu; Huang, Ming Shyan; Lin, Hsien Chih; Seow, Adeline; Park, Jae Yong; Kweon, Sun Seog; Chen, Chien Jen; Gao, Yu Tang; Wu, Chen; Qian, Biyun; Lu, Daru; Liu, Jianjun; Jeon, Hyo Sung; Hsiao, Chin Fu; Sung, Jae Sook; Tsai, Ying Huang; Jung, Yoo Jin; Guo, Huan; Hu, Zhibin; Chen, Tzu Yu; Burdett, Laurie; Yeager, Meredith; Hutchinson, Amy; Berndt, Sonja I.; Wu, Wei; Wang, Junwen; Choi, Jin Eun; Park, Kyong Hwa; Sung, Sook Whan; Liu, Li; Kang, Chang Hyun; Chen, Chung Hsing; Xu, Jun; Guan, Peng; Tan, Wen; Wang, Chih Liang; Loon Sihoe, Alan Dart; Chen, Ying; Choi, Yi Young; Kim, Jun Suk; Yoon, Ho Il; Cai, Qiuyin; Park, In Kyu; Xu, Ping; He, Qincheng; Chen, Chih Yi; Wu, Junjie; Lim, Wei Yen; Chen, Kun Chieh; Chan, John K.C.; Li, Jihua; Chen, Hongyan; Yu, Chong Jen; Jin, Li; Fraumeni, Joseph F.; Liu, Jie; Landi, Maria Teresa; Yamaji, Taiki; Yang, Yang; Hicks, Belynda; Wyatt, Kathleen; Li, Shengchao A.; Ma, Hongxia; Song, Bao; Wang, Zhehai; Cheng, Sensen; Li, Xuelian; Ren, Yangwu; Iwasaki, Motoki; Zhu, Junjie; Jiang, Gening; Fei, Ke; Wu, Guoping; Chien, Li Hsin; Tsai, Fang Yu; Yu, Jinming; Stevens, Victoria L.; Yang, Pan Chyr; Lin, Dongxin; Chen, Kexin; Wu, Yi Long; Matsuo, Keitaro; Rothman, Nathaniel; Shiraishi, Kouya; Shen, Hongbing; Chanock, Stephen J.; Kohno, Takashi; Lan, Qing; IRAS – One Health Chemical; IRAS OH Epidemiology Chemical Agents |
| Publication Year: |
2025 |
| Subject Terms: |
EGFR mutation; Lung adenocarcinoma; Never-smokers; Polygenic risk score; Taverne; Oncology; Pulmonary and Respiratory Medicine; SDG 3 - Good Health and Well-being |
| Description: |
We assessed the association between a genome-wide polygenic risk score (PRS) developed for lung adenocarcinoma (LUAD) risk and mutation on the EGFR gene in 998 East Asian never-smoking female LUAD cases (518 EGFR-positive; 480 EGFR-negative) and 4544 never-smoking controls using case-case and multinomial regression analyses. We found that the PRS was more strongly associated with EGFR-positive LUAD compared with EGFR-negative LUAD, where the association between the fourth quartile of the PRS and EGFR-positive LUAD (odds ratio = 8.63, 95% confidence interval: 5.67–13.14) was significantly higher than the association between the fourth quartile of the PRS with EGFR-negative LUAD (odds ratio = 3.50, 95% confidence interval: 2.44–5.00) (p-heterogeneity = 3.66 × 10−3). Our findings suggest that germline genetic susceptibility may be differentially associated with LUAD in never-smoking female East Asian patients depending on the cancer's mutation status, which may have important public health and clinical implications. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1556-0864 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/475077 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/475077 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.6D924324 |
| Database: |
BASE |