| Title: |
Convergent Synthesis of Template‐Assembled Synthetic G‐Quartets (TASQs) Used as Biomimetic and Multivalent G‐Quadruplex (G4) Ligands |
| Authors: |
Raevens, Sandy; Desingle, Cécile; Pirrotta, Marc; Sperti, Francesco, Rota; Pieri, Andréa; Lejault, Pauline; Valverde, Ibai, E; Monchaud, David |
| Contributors: |
Institut de Chimie Moléculaire de l'Université de Bourgogne Dijon (ICMUB); Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Bourgogne Europe (UBE); This work was supported by the CNRS MITI (to S.R. and D.M.), CNRS (to I.E.V. and D.M.), UBE (to C.D. and M.P.), Agence Nationale de la Recherche (to D.M., ANR-22-CE44-0039-01 and ANR-24-CE44-1817-03) and Ligue contre le Cancer (to D.M.). The authors thank Prof. Franck Denat for helpful discussions and Baptiste Dupouy for his help in the AMC synthesis.; ANR-24-CE44-1817,TOP2-G4,Comprendre et moduler les propriétés cellulaires des ligands de G-quadruplexes(2024); ANR-22-CE44-0039,InJUNCTION,Des outils moléculaires pour l'étude des jonctions d'ADN(2022) |
| Source: |
ISSN: 0947-6539. |
| Publisher Information: |
CCSD; Wiley-VCH Verlag |
| Publication Year: |
2025 |
| Collection: |
Université de Bourgogne (UB): HAL |
| Subject Terms: |
macrocycles; chemical biology; molecular tools; synthetic G-quartet; TASQ; Synthesis design; G-quadruplexes; [CHIM]Chemical Sciences |
| Description: |
International audience ; Precise insights into the biology of DNA and RNA G-quadruplexes (G4s) were obtained thanks to the use of ever more versatile G4-interacting molecules (or G4 ligands), which bear additional moieties making them functionalizable in situ (i.e., while in interaction with cellular G4s) thanks to bioorthogonal chemistry. We recently reported on a series of biomimetic G4 ligands known as TASQs (for template-assembled synthetic G-quartets) whose multifunctionality was exploited to visualize (pre-targeted and in situ click imaging) and identify cellular G4s (G4omics and Chem-CLIP). We report herein on a novel synthetic strategy that makes multivalent TASQs readily accessible and opens brand new perspectives for the design of ever smarter molecular tools to unravel the quite complex G4 biology in a more accurate, straightforward, and simpler manner. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41267487; PUBMED: 41267487 |
| DOI: |
10.1002/chem.202503002 |
| Availability: |
https://hal.science/hal-05384162; https://hal.science/hal-05384162v1/document; https://hal.science/hal-05384162v1/file/DM%20-%20CAEJ%20-%202025%20-%20in%20press.pdf; https://doi.org/10.1002/chem.202503002 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.6DBAE012 |
| Database: |
BASE |