| Title: |
Vitamin D therapy in chronic kidney disease: a critical appraisal of clinical trial evidence |
| Authors: |
Yeung, W-CG; Toussaint, ND; Badve, SV |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2024 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
In people with chronic kidney disease (CKD), the physiology of vitamin D is altered and leads to abnormalities in bone and mineral metabolism which contribute to CKD mineral and bone disorder (CKD-MBD). Observational studies show an association between vitamin D deficiency and increased risk of mortality, cardiovascular disease and fracture in CKD. Although vitamin D therapy is widely prescribed in people with CKD, clinical trials to date have failed to demonstrate a clear benefit of either nutritional vitamin D supplementation or active vitamin D therapy in improving clinical outcomes in CKD. This review provides an updated critical analysis of recent trial evidence on vitamin D therapy in people with CKD. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
2048-8505 |
| Relation: |
pii: sfae227; https://hdl.handle.net/11343/349997 |
| Availability: |
https://hdl.handle.net/11343/349997 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.6DC328C3 |
| Database: |
BASE |