| Title: |
Genetically determined body mass index is associated with diffuse large B-cell lymphoma in polygenic and Mendelian randomization analyses |
| Authors: |
Moore, A; Kane, E; Teras, LR; Machiela, MJ; Arias, J; Panagiotou, OA; Monnereau, A; Doo, NW; Wang, Z; Slager, SL; Vermeulen, RCH; Vajdic, CM; Smedby, KE; Spinelli, JJ; Vijai, J; Giles, GG; Link, BK; Arslan, AA; Nieters, A; Bracci, PM; Camp, NJ; Salles, G; Cozen, W; Hjalgrim, H; De Vivo, I; Adami, HO; Albanes, D; Becker, N; Benavente, Y; Bisanzi, S; Boffetta, P; Brennan, P; Brooks-Wilson, AR; Canzian, F; Clavel, J; Conde, L; Cox, DG; Curtin, K; Foretova, L; Ghesquières, H; Glimelius, B; Habermann, TM; Hofmann, JN; Lan, Q; Liebow, M; Lincoln, A; Maynadie, M; McKay, J; Melbye, M; Miligi, L; Milne, RL; Molina, TJ; Morton, LM; North, KE; Offit, K; Padoan, M; Piro, S; Patel, AV; Purdue, MP; Ravichandran, V; Riboli, E; Severson, RK; Southey, MC; Staines, A; Tinker, LF; Travis, RC; Wang, SS; Weiderpass, E; Weinstein, S; Zheng, T; Chanock, SJ; Rothman, N; Birmann, BM; Cerhan, JR; Berndt, SI |
| Publisher Information: |
Wiley |
| Publication Year: |
2026 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-hip ratio adjusted for BMI (WHRadjBMI). Higher genetically determined BMI was associated with an increased risk of DLBCL [odds ratio (OR) per standard deviation (SD) = 1.18, 95% confidence interval (95% CI): 1.05-1.33, p = .005]. This finding was consistent with Mendelian randomization analyses, which demonstrated a similar increased risk of DLBCL with higher genetically determined BMI (ORper SD = 1.12, 95% CI: 1.02-1.23, p = .03). No significant associations were observed with other NHL subtypes. Our study demonstrates a positive link between a genetically determined BMI and an increased risk of DLBCL, providing additional support for increased adiposity as a risk factor for DLBCL. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0020-7136 |
| Relation: |
https://hdl.handle.net/11343/362406 |
| Availability: |
https://hdl.handle.net/11343/362406 |
| Rights: |
https://creativecommons.org/licenses/by/4.0 ; CC BY |
| Accession Number: |
edsbas.6E1FE42E |
| Database: |
BASE |